肝脏原发性囊性成熟性畸胎瘤合并腺癌临床病理分析  

Primary malignant teratoma of liver:a clinicopathologic analysis

作　　者：李燕[1] 贺海燕[1] 李晶[1] 张淼[1] 

机构地区：[1]宁夏自治区人民医院,宁夏银川750021

出　　处：《宁夏医学杂志》2009年第5期437-438,F0003,共3页Ningxia Medical Journal

摘　　要：目的探讨肝脏恶性畸胎瘤的临床病理特点、诊断和预后。方法对1例肝脏原发性恶性畸胎瘤进行光镜、免疫组织化学观察并结合文献分析。结果患者为62岁男性,肝脏肿瘤大小为20.0 cm×15.0 cm×10.0 cm,肿瘤为囊实性,呈三胚层分化,可见成熟鳞状上皮、汗腺、皮脂腺、脂肪、软骨、甲状腺、气管等组织,恶性成分为消化道黏液腺癌并有2个肝内转移灶。免疫组化标记:EMA、CEA、PCNA、GST-π、nm23为(+)、AFP、P53、P170、topoⅡ为(-)。结论老年男性肝脏原发性恶性畸胎瘤十分罕见,尤其在老年男性腺癌变伴肝内转移文献上还未见报道。术前诊断困难,诊断依赖于CT、病理组织学、免疫组化。Objective To investigate the clinical characteristic, diagnosis and prognosis of malignant teratoma of liver. Methotis One case of malignemt teratoma of liver was analyzed with light microscopic and immunohistochemical observation and related literature was reviewed. Results The tumor was in cystic and solid areas with three germinal. Histologically, the tumor composed of mature benign epithelial, lipcyte, chondro, thyroid and tracheal. Malignant composes was mucinous adenocarcinoma, and metastetic with Two ned in liver. Immunohistochemically, the tumor cells were positive for EMA, CEA, PCNA, GST - π, nm23 and negative AFP, P53, P170 and topo Ⅱ. Conclusion This is the first case report of adult liver cystic mature teratoma with malignant transformation in the literature. The diagnosis is based on its CT, Pathological morphology and immunohistochemical staining.

关 键 词：肝脏 恶性畸胎瘤 临床病理 

分 类 号：R735.7[医药卫生—肿瘤]