醋酸甲羟孕酮原位凝胶植入剂的制备及体外药物释放评价  

Preparation and Evaluation of In Situ Gel Implants Containing Medroxy Progesterone Acetate(MPA-PLA) In Vitro

作　　者：李婷婷[1] 曾忠良[1] 陈刚莲[2] 胡启飞[1] 

机构地区：[1]西南大学药学院,重庆北碚400716 [2]重庆康刻尔制药有限公司,重庆401122

出　　处：《中国兽药杂志》2009年第5期2-4,共3页Chinese Journal of Veterinary Drug

摘　　要：采用正交设计法对醋酸甲羟孕酮原位凝胶植入剂(MPA-PLA)进行处方筛选,优化制备工艺。以高效液相为检测方法,评价该制剂的体外释放规律。结果显示:MPA-PLA能显著延长释放时间,具有长效缓释制剂的基本释药规律。The optimal prescription was selected to prepare MPA - PLA and the release of MPA - PLA in vitro was determined by a rapid and sensitive high - performance liquid chromatography （HPLC） assay . The results show that MPA- PLA has long- term sustained release.

关 键 词：原位凝胶植入剂 正交设计 体外评价 长效缓释 

分 类 号：R914.2[医药卫生—药物化学]