无抽搐电休克治疗对认知功能的影响  

The effects of modified electric convulsive therapy on cognitive function

作　　者：钱卫娟[1] 范俭雄[1] 周群[1] 高晓宁[1] 

机构地区：[1]南京医科大学附属脑科医院,210029

出　　处：《四川精神卫生》2009年第2期78-80,共3页Sichuan Mental Health

基　　金：南京医科大学科技发展基金(NY04043)

摘　　要：目的评价无抽搐电休克治疗(MECT)对认知功能的影响。方法对24例精神疾病患者在MECT前及MECT后5～7天内进行威斯康星卡片分类、连线试验A和B、数字广度、数字符号和临床记忆量表等神经心理学测验。结果①威斯康星卡片分类中,患者完成的总应答数(Ra)在MECT治疗后较治疗前显著减少(P<0.05);②连线试验A和B中,患者完成时间在MECT治疗后较治疗前显著缩短(P<0.05);③数字广度中,患者在MECT治疗后较治疗前显著增加(P<0.05);④数字符号中,患者在MECT治疗后较治疗前差异无显著性(P>0.05);⑤临床记忆量表中各项指标,患者在MECT治疗后较治疗前差异均无显著性(P均>0.05);⑥精神疾病患者在MECT治疗后精神症状得到控制,病情恢复良好。结论MECT对认知功能无明显损害,对重性精神障碍患者疗效好。Objective To estimate the effects of modified electric convulsive therapy（MECT） on cognitive function. Method Twenty- four participants were assessed by Wisconsin Card Sorting Test （WCST）, trail making test A and B, Digit Span Test（ DST）, Digit -Symbol Substitution Test and Clinical Memory Score（CMS） at pre - and post - MECT. Results The total trials of WCST were significantly reduced at post - treatment than pre - treatment （ P 〈 0.05 ） ; In trail making test A and B,the finished - time was significantly shorter at post - treatment than pre - treatment （ P 〈 0. 05 ） ; In DST, there were significantly improved after treatment than before（ P 〈 0. 05 ） ;No significant difference was observed between pre -treatment and post- treatment in Digit -Symbol Substitution Test（ P 〉0. 05 ） ;No significant difference was observed between pre- treatment and post- treatment in the Clinical Memory Score（ all P 〉 0. 05 ） ;Psychiatric symptoms were well- controlled and pathogenetic condition had good improvement. Conclusion MECT do not damage the cognitive function signifieantly;MECT have good therapeutic effect on multiplicity mental disorder patients.

关 键 词：无抽搐电休克治疗 神经心理学测验 认知功能 

分 类 号：R749.054[医药卫生—神经病学与精神病学] R749.3[医药卫生—临床医学]