左氧氟沙星配伍甲硝唑治疗急性化脓性阑尾炎疗效分析  

EFFICACY ANALYSIS OF LEVOFLOXACIN PLUS METRONIDAZOLE IN TREATMENT OF PATIENTS WITH ACUTE PURULENT APPENDICITIS

作　　者：苏玉严[1] 

机构地区：[1]海南省农垦总局医院药剂科,海口570311

出　　处：《现代预防医学》2009年第10期1994-1995,共2页Modern Preventive Medicine

摘　　要：[目的]评价左氧氟沙星配伍甲硝唑治疗急性化脓性阑尾炎的疗效和不良反应。[方法]78例急性化脓性阑尾炎术后病例随机分为左氧氧沙星配伍甲硝唑治疗组（Lev组，n=40）与头孢曲松钠配伍甲硝唑治疗组（Cef组，n=38），术后抗菌治疗平均6-8d，观察术后切口感染发生率、腹腔感染发生率与不良反应发生率。[结果]左氧氟沙星配伍甲硝唑组的切口感染率、腹腔感染率和不良反应率分别为12．5％、5．0％、17．5％，头孢曲松钠配伍甲硝唑组的术后切口感染率、腹腔感染率和不良反应率分别为10.5％、5．2％、15．8％，两者差异无统计学意义（P〉0．05）。[结论]左氧氟沙星配伍甲硝唑与头孢曲松钠配伍甲硝唑治疗急性化脓性阑尾炎同样有效，不良反应相似。[Objective] To evaluate the clinical therapeutic effect and adverse events of levofloxacin plus metronidazole in treatment of patients with acute purulent appendicitis. [Methods] A total of 78 cases with acute purulent appendicitis were randoady divided into levofloxaein plus metronidazole group （Lev group, n=40） and eeftriaxone plus metronidazole group （Cef gruoup, n=38）. The average time of antibiosis treatment after operation was at the range of 6 to 8 days. The rates of wound infection, abdominal infection and adverse events in every group wero analyzed respectively. [Results] In Lev group, the incidence of wound infection, abdominal infection and adverse events was 12,5%, 5.0% and 17.5%, respectively, and in Cef group were 10.5%, 5.2% and 15.8%, respectively. There was no significant difference between two groups （P 〉 0.05）. [Conclusion] The effect of levofloxaein plus metronidazole was proved to be same safe and effective as that of eeflriaxone plus metronidazole.

关 键 词：左氧氟沙星 甲硝唑 头孢曲松钠 急性化脓性阑尾炎 疗效 

分 类 号：R574.61[医药卫生—消化系统]