胃肠道间质瘤病理学因素与预后的相关性研究  

Study of correlation of pathology factors and prognosis of gastrointestinal stroma tumor

作　　者：白文启[1] 米哲涛[2] 梁小波[1] 李红英[3] 郗彦凤[4] 

机构地区：[1]山西省肿瘤医院肛肠科,太原030013 [2]山西省肿瘤医院放疗技术室,太原030013 [3]山西省肿瘤医院体检中心,太原030013 [4]山西省肿瘤医院病理科,太原030013

出　　处：《肿瘤研究与临床》2009年第5期341-342,345,共3页Cancer Research and Clinic

摘　　要：目的探讨胃肠道间质瘤（GIST）病理学因素与预后的相关性。方法应用免疫组织化学Envision法对91例GIST进行CD117、CD34、SMA、S-100、Ki-67的标记，应用SPSS12．0软件分析肿瘤的部位、大小、出血、坏死、间质黏液、核分裂象及Ki-67与预后的相关性。结果91例GISTCD117、CD34SMA、S-100的阳性率分别为：80．21％、73．63％、34．07％、7．69％，肿瘤大小、核分裂象、Ki-67的表达与预后差异有显著相关性，出血、坏死、间质黏液、CD117的表达与预后无显著相关性。结论肿瘤大小、核分裂象、Ki-67的表达与预后有相关性。Ki-67的表达相对于核分裂象在判断肿瘤生物学行为方面是一个更为准确的指标，Flecther分级法是一种值得推广的分级方法。Objective To investigate the correlation of pathology factors and prognosis of gastrointestinal stroma tumors （GIST）. Methods The expression of CD117, CD34, SMA, S-100 and Ki-67 in 91 GIST cases were studied by Envision method of immunohistochemistory; Sequently, the relationship of the location, the size, the hemorrhage, cellular necrosis, stroma mucus, the mitosis, Ki-67 expression and the prognosis were analyzed by SPSS 12.0. Results The positive rate of CD117, CD34, SMA, S-100 were 80.21%, 73.63 %, 34.07 %, 7.69 % respectively. There had significant difference between the location, the mitosis, Ki-67 expression and the prognosis; but no significant difference between the location, the hemorrhage, cellular necrosis, stroma mucus, CD117 expression and the prognosis. Conclusion The tumor＇s size, mitosis, and Ki-67 expression are associated with prognosis; CD117 expression and prognosis. Even more, Ki-67 expression may be a more precise factor to judge the tumor＇ s biological behaviour compared to the mitosis. As a wally classified method, the Fleether classification is worth to spread.

关 键 词：胃肠道间质肿瘤 病理学 CD117 KI-67 预后 

分 类 号：R735[医药卫生—肿瘤] R735.2[医药卫生—临床医学]