血管性痴呆高脂血症患者血清HCY与hs-CRP临床研究  

Clinical research of homocysteine and high-sensitive C-reactive protein in patients of vascular dementia with hyperlipoidemia

作　　者：蔡志友[1] 晏勇[1] 晏宁[1] 王凤英[2] 郭坪生 叶燕 唐秦 王咏龙[1] 赵宇[1] 

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆400016 [2]遵义医学院附属医院神经内科 [3]重庆市第三社会福利院 [4]重庆市第二社会福利院 [5]重庆市西郊医院

出　　处：《中国老年学杂志》2009年第10期1231-1233,共3页Chinese Journal of Gerontology

基　　金：国家民政部中国老年学学会(2007-18-3-05)

摘　　要：目的检测血管性痴呆(VD)伴高血脂患者血清HCY、hs-CRP、IL-1β、TNF-α浓度值和血脂水平值,探讨VD患者血脂异常和HCY、hs-CRP在VD发病机制中的关系和作用。方法实验分为4组:非VD血脂正常组(N组)、非VD高血脂组(H组)、VD血脂正常组(V组)、VD高血脂组(VH组),双抗体夹心ELISA法测定hs-CRP、IL-1β、TNF-α,采用荧光标记免疫检测法血清HCY水平,生物化学法测定血脂。结果VH、V、H组和N组比较HCY、hs-CRP、IL-1β、TNF-α浓度显著增高;VH组和H、V组比较HCY、hs-CRP、IL-1β、TNF-α浓度明显增高;H组和V组比较无显著性差异。全部VD患者MMSE评分和HCY、hs-CRP浓度值具有负相关性。结论HCY、hs-CRP参与了VD的发病机制,血脂代谢异常通过增强HCY、hs-CRP表达这一途径也参与VD发病机制。Objective To detect serum level of homocysteine （HCY）, high-sensitive C-reactive protein （hs-CRP）, IL-1β and TNF-α in vascular dementia （VD） patients with hyperlipoidemia, and explore the relationship and effect of dyslipidemia, HCY and hs-CRP in VD. Methods Subjects were divided into normal blood lipid level group without VD （N）, higher blood lipid level group without VD （H）, normal blood lipid level group with VD （V）, higher blood lipid level group with VD （VH）. Hs-CRP, IL-1β and TNF-α were measured by ELISA, HCY was measured by immunofluorescence, and blood lipid level was measured by biochemistry. Results The serum level of HCY, hs-CRP, IL-1β and TNF-α in VH, V, H groups were significantly higher than those of N group. The serum level of HCY, hs- CRP, IL-1β, TNF-α in VH group were significantly higher than those of H and V groups. The serum level of HCY, hs-CRP, IL-1β and TNF-α in V group had no significant differences compared with those of H group. The score of mini-mental state examination （MMSE） in all VD had opposite correlation with the serum level of hs-CRP and HCY. Conclusions HCY and hs-CRP participate in pathogenesis of VD. Dyslipidemia participate in the mechanism of the development of VD, which come ture by increasing the expression of HCY and hs-CRP.

关 键 词：血管性痴呆 同型半胱氨酸 高敏C反应蛋白 高血脂 

分 类 号：R743[医药卫生—神经病学与精神病学]