肺癌组织中HSG、p21和PCNA的表达及意义  

Expression of HSG,p21^(WAF1) and PCNA and their significance in lung cancer

作　　者：丁焕然[1] 姜广建[1] 马小兵[1] 苗丽娟[1] 夏庆安[1] 马立人[1] 

机构地区：[1]华北煤炭医学院临床医学系,唐山063000

出　　处：《临床与实验病理学杂志》2009年第2期147-150,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金资助(30770247);河北省自然科学基金资助(C2007000894)

摘　　要：目的探讨细胞增殖抑制基因(HSG)、p21WAF1、增殖细胞核抗原(PCNA)在肺癌中的表达及其相关性。方法采用免疫组化SP法检测92例肺癌(鳞、腺癌)组织中HSG、p21WAF1和PCNA的表达。结果HSG在肺癌组织中的表达与组织学分型、分化程度有关(P<0.01、P<0.001);p21WAF1在肺癌组织中的表达与分化程度、淋巴结转移有关(P<0.001、P<0.01);PCNA在肺癌组织中的表达与分化程度、淋巴结转移有关(P<0.001)。HSG与p21WAF1在肺癌组织中的表达呈正相关(r=0.34,P<0.05);HSG与PCNA在肺癌组织中的表达呈负相关(r=-0.41,P<0.05);p21WAF1与PCNA在肺癌组织中的表达呈负相关(r=-0.49,P<0.05)。结论HSG、p21WAF1和PCNA的表达与肺癌的发生、发展密切相关。Purpose To investigate the expression of hyperplasia suppressor gene （ HSG）, p21^WAF1 and proliferating cell nuclear antigen （PCNA） in lung cancer. Methods The expression of HSG, p21^WAF1, PCNA was detected in 92 cases of lung cancer （ squamous cell carcinoma, adenocarcinoma of lung） by immunohistochemistry. Results The expression of HSG in lung cancer was associated with histological type and tumor differentiation（ P 〈 0. 01, P 〈 0. 001 ）. The expression of p21^WAF1 was closely associated with tumor differentiation and lymph node metastasis （ P 〈 0. 001, P 〈 0. 01 ）. The expression of PCNA was closely associated with tumor differentiation and lymph node metastasis（P 〈0. 001 ）. There is a positive correlation between HSG and p21^WAF1 in lung cancer（ r = 0. 34, P 〈 0. 05 ）. There were negative correlation between HSG and PCNA（ r = -0. 41, P 〈 0. 05 ） and the same between p21^WAF1 and PCNA（ r = - 0. 49,P 〈 0. 05 ）. Conclusion HSG, p21^ WAF1 and PCNA are closely related to the pathogenesis and development of lung cancer.

关 键 词：肺肿瘤 细胞增殖抑制基因 P21WAF1 增殖细胞核抗原 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]