肾虚骨痛胶囊对去势大鼠股骨无机元素含量和骨灰重量的影响  

Influence of Shenxu Gutong Capsule on Femoral Inorganic Elements Content and Ash Weight in Rats

作　　者：陈训华[1] 危剑安[2] 陈燕平[1] 丁继华[1] 周重光[1] 李维超 张万强[1] 高云[1] 

机构地区：[1]中国中医研究院骨伤科研究所,北京100700 [2]中国中医研究院广安门医院 [3]北京师范大学测试中心

出　　处：《中国中西医结合杂志》1998年第2期101-103,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局科研基金!922187

摘　　要：探讨肾虚骨痛胶囊防治骨质疏松症的机理。方法：本实验以切除卵巢大鼠复制绝经后骨质疏松模型，观察该药对去势大鼠股骨无机元素含量及股骨骨灰重量的影响。实验分为模型组、肾虚骨痛胶囊大、小剂量组、骨疏康阳性对照组以及正常对照组。术后１周开始给药，持续 １２０天。结果： ３个给药组股骨无机元素 Ｃａ、 Ｐ、 Ｍｇ、 Ｚｎ、Ｃｕ、 Ｍｎ含量明显高于模型组（ Ｐ＜ ０． ０１），两个剂量组间有一定量效关系，与阳性对照组无显著性差异。大剂量组和骨疏康组股骨灰重明显高于模型组（ Ｐ＜ ０． ０１）。结论：肾虚骨痛胶囊确能对抗去势大鼠骨质改变，增加骨内无机元素含量，达到壮骨之效。To explore the mechanism of Shenxu Gutong Capsule (SXGTC) in treating postmenopausal osteo porosis. Methods: Using ovariectomized rats as the model of postmentopausal osteoporosis, the effect of SXGTC on inorganic element content of femur and femoral ash weight of the model rats were surveyed. Animals were divided into model group, SXGTC high dose group, SXGTC low dose group, positive control group (treated with Gushukang) and normal control group. The medication began at one week after operation and lasting for 120 days. Results: The contents of inorganic elements, including Ca, P, Mg, Zn, Cu and Mn in the three medicated groups were higher than those of the model group (P<0.01). The effect of SXGTC was dose dependent. The difference between the SXGTC groups and the active control group was insignificant. The femoral ash weight of the SXGTC high dose group and the active control group was significantly higher than that of the model group (P < 0. 01). Conclusions: SXGTC could antagonize the rat's bony change caused by ovariectomy to increase the inorganic contents in bone, which may, in grneral, lead to a bone-strengthening effect.

关 键 词：肾虚骨痛胶囊 骨质疏松 卵巢切除 无机元素 

分 类 号：R274.91[医药卫生—中西医结合]