p53和nm23在大肠癌中的表达及其生物学意义  

EXPRESSIONS OF p53 AND nm23 GENES AND THEIR BIOLOGICAL SIGNIFICANCE IN HUMAN COLORECTAL CARCINOMA

作　　者：李玉军[1] 姜天福[1] 张顺[1] 孙显路 纪祥瑞[1] 

机构地区：[1]青岛医学院附属医院

出　　处：《青岛医学院学报》1998年第2期100-101,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的探讨大肠癌组织中ｐ５３及ｎｍ２３的表达与浸润转移的关系。②方法应用免疫组织化学ＬＳＡＢ法检测７５例大肠癌中ｐ５３及ｎｍ２３的表达。③结果大肠癌组织中ｐ５３，ｎｍ２３的阳性率分别为５３．３％和６５．３％．ｐ５３过表达和ｎｍ２３低表达均与大肠癌的浸润深度及淋巴结转移有关。ｐ５３在低分化癌中的表达明显高于高分化癌（χ２＝１０．０８，Ｐ＜０．０１），而ｎｍ２３表达与大肠癌分化程度无关（χ２＝３．３９，Ｐ＞０．０５）。④结论ｐ５３高表达和ｎｍ２３低表达在大肠癌的浸润转移中起重要作用。Objective To study the relationship between invasion, metastasis and the expression of p53 and nm23 gene protein in human colorectal carcinoma. Methods The expressions of p53 and nm23 genes in 75 human colorectal carcinomas were studied with LSAB immunohistochemical technique. Results The positive rates of p53 and nm23 protein staining were 53. 3%and 65.3%,respectively. A significant correlation was found between p53 protein overexpression, nm23 low exression and the depth of invasion and lymph node metastasis. The expression of p53 in poorly differentiatied carcinoma was significantly higher than that in well differentiated carcinoma( χ 2=10.08,P <0.01), while the expression of nm23 showed no relation with the differentiation of carcinoma( χ 2=3.39,P> 0.05). Conclusion p53 overexpression and nm23 low expression might play an important role in the invasion and metastasis of human colorectal carcinoma.Abnormality of multi genes may be invoved in lymph node metastasis of human colorectal carcinoma.

关 键 词：大肠肿瘤 基因表达 P53基因 NM23基因 

分 类 号：R735.340.2[医药卫生—肿瘤]