奥沙利铂联合5-氟脲嘧啶和醛氢叶酸钙时辰化疗26例进展期胃癌的临床观察  

The Clinical Oberservation Chronotherapy of Combined 5-Fluorouracil Oxaliplatin and Leucovor in for Advanced Gastric Cancer

作　　者：王洪武[1] 

机构地区：[1]赤峰市医院肿瘤外科,内蒙古赤峰024000

出　　处：《内蒙古医学杂志》2009年第4期422-423,共2页Inner Mongolia Medical Journal

摘　　要：目的:观察奥沙利铂(L-OHP)联合5-氟脲嘧啶(5-Fu)、醛氢叶酸钙(FA)方案(FFL)时辰输注法治疗晚期胃癌的疗效和不良反应。方法:FFL方案时辰输注治疗26例晚期胃癌患者,L-OHP每天25mg/m2、5-Fu每天600 mg/m2、FA每天300 mg/m2,四通道程控时辰输液泵连续给药4 d,每14 d为1个周期,至少用2个周期。结果:26例晚期胃癌患者中,完全缓解(CR)2例(7.7%),部分缓解(PR)13例(50.0%),稳定(SD)6例(23.1%),进展(PD)5例(19.2%),总有效率为57.7%。在80个周期的化疗中,最常见的不良反应为血液学毒性、胃肠道毒性、外周神经毒性,但均以Ⅰ度为主,2例发生Ⅲ度中性粒细胞减少,血小板减少、呕吐和口腔黏膜炎分别发生1例次,未出现Ⅳ度不良反应。中位缓解时间为3.5个月,中位肿瘤进展时间为4.5个月,全组患者中位生存期为8个月。结论:FFL方案时辰输注法是治疗晚期胃癌安全有效的化疗方案。Objective： To observation effect and side reaction chronotherapy of combined 5 - Fu,Oxaliplatin and Leucovorin for advanced gastric cancer. Method： We use multichannel programmable infusion pump for 26 cases advanced gastric cancer total 4 days. Which was repeated every 2 -- 3 weeks for at least 2 cycles. Reasult： Of 26 cases, 2 cases （7.7 % ） complete remission, 13 cases（50.0 % ） partial remission, 6 cases（23.1% ） stable disease, 5 cases（ 19.2 % ）progressive disease, total response rate 57.7 %. Total 80 cycles chemotherapy. Most common adverse reaction is hematology toxity, gastrointestinal toxity, peripheral nerve toxity, most of them 1 grade. 3 grade neutropeni, thrombocytopenic, vomiting, oral mucosa inflammation. No 4 grade adverse reaction. Median remission duration 3. 5 months, Median tumor progress duration 4, 5 months. Median survival duration 8 months. Conclusion： FFL chronotherapy is safty and effective methods for advanced gastric cancer.

关 键 词：胃肿瘤 奥沙利铂 5-氟脲嘧啶 醛氢叶酸钙 时辰化疗 

分 类 号：R735.2[医药卫生—肿瘤]