肺癌上皮-间质转变现象的研究进展  

Research progress in epithelial-mesenchymal transition phenomenon in lung cancer

作　　者：叶挺[1] 蒋伟[1] 逄旭光[1] 王群[1] 

机构地区：[1]复旦大学附属中山医院胸外科,上海200032

出　　处：《复旦学报（医学版）》2009年第3期372-375,共4页Fudan University Journal of Medical Sciences

摘　　要：近几年来对于恶性肿瘤上皮-间质转变(epithelial-mesenchymal transition,EMT)现象的研究成为了防治恶性肿瘤的研究热点。国内外的研究发现恶性肿瘤如卵巢癌、前列腺癌、胃癌等中EMT现象参与恶性肿瘤局部淋巴结及远处脏器的转移,并发现EMT现象中主要的分子蛋白及信号通路。对于死亡率最高的恶性肿瘤肺癌中EMT现象的研究也取得了一定的成果。本文对于肺癌EMT现象中相关诱导分子及信号通路等方面的研究成果作一综述,希望通过总结分析,明确以后的研究方向,进一步探索肺癌等恶性肿瘤的分子靶向治疗方式。More researches focus on epithelial-mesenchymal transition （EMT） phenomenon in malignant tumor in recent years. These researches reveal that EMT phenomenon in several tumors such as ovary cancer, prostate cancer and gastric cancer is involved in local lymph nodes and remote organs metastasis. The relevant molecule proteins and signal pathways are also studied. Researches on EMT phenomenon in lung cancer also make a lot of progress. In this article, the research progress in relevant molecules and signal pathways in EMT in lung cancer was reviewed.

关 键 词：肺癌 上皮-间质转变 信号通路 

分 类 号：R730.2[医药卫生—肿瘤]