Novel Efficient Method for Synthesis of N_(1,4)-Disubstituted-1,4-benzodiazepine-2,5-diones  

作　　者：WANG Qiu-yan YU Jing-jun LU Cui-fen CHEN Zu-xing YANG Gui-chun 

机构地区：[1]Key Laboratory for the Synthesis and Application of Organic Functional Molecules of Ministry of Education, School of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P. R. China

出　　处：《Chemical Research in Chinese Universities》2009年第3期312-316,共5页高等学校化学研究（英文版）

基　　金：Supported by the Natural Science Foundation of Hubei Province, China(No.2007ABA031)

摘　　要：A novel and efficient method was developed for the liquid-phase synthesis of Nj,4-disubstitutedbenzodiazepine-2,5-diones with 2-chloro-5-nitrobenzoic acid as initiating material via 4 step reactions containing esterifieation, ＂Ulmn reaction＂, acylation, alkylation and cyclization. The reaction conditions were mild and the overall yields of the products ranged from 45% to 71%.A novel and efficient method was developed for the liquid-phase synthesis of Nj,4-disubstitutedbenzodiazepine-2,5-diones with 2-chloro-5-nitrobenzoic acid as initiating material via 4 step reactions containing esterifieation, ＂Ulmn reaction＂, acylation, alkylation and cyclization. The reaction conditions were mild and the overall yields of the products ranged from 45% to 71%.

关 键 词：1 4-Benzodiazepine-2 5-dione Liquid-phase DIPEPTIDES 

分 类 号：O623.523[理学—有机化学] TQ246.16[理学—化学]