胃癌侵袭性及其根治手术对病人血清转化生长因子β1浓度的影响  

The influence of aggressiveness and radical operation of gastric cancer on serum transforming growth factor β1 level in the patients.

作　　者：许洪卫[1] 王元和[1] 谭龙益[1] 

机构地区：[1]第二军医大学长征医院外科,上海200003

出　　处：《中华实验外科杂志》1998年第4期320-321,共2页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(No.39570786)

摘　　要：目的探讨转化生长因子β1(TGFβ1)对人胃癌侵袭性的作用。方法应用酶联免疫吸附法测定29例胃癌病人血清TGFβ1浓度;应用点杂交法分析癌灶组织的TGFβ1 mRNA水平。结果浸润型组或伴有淋巴结转移组的血清TGF β1浓度和TGFβ1 mRNA表达水平分别明显高于膨胀型组或无淋巴结转移组(P<0.05～0.01),切除瘤体后上述各组的血清TGFβ1浓度均明显下降(P<0.05～0.001)。结论 TGFβ1可能与人胃癌的浸润和转移密切相关。Objective To detect the role of transtorming growth tactor β1 (TGF β1) on the aggressiveness ot human gastric cancer. Methods Using ELISA, fasting concentration of serum TGFβ1 was determined in 29 patients with gastric cancer before and after radical operation. The expression of TGFβ1 mRNA in the tumor was analyzed by dot blot. Results The serum TGFβ1 concentration and the TGFβ1 mRNA expression level in the groups with invasiveness or with metastatic lymph nodes were significantly high-er than those in the groups with expansion or without metastatic lymph nodes (P<0.05-0.01), respec-tively. After the removal of the tumors, the TGFβ1 concentration was dramatically decreased (P<0.05-0.01) in all groups. Conclusion Serum TGFβ1 may be a factor associated with the invasive and metastatic potential of gastric carcinomas.

关 键 词：转化生长因子 胃癌 侵袭性 外科手术 TGFΒ1 

分 类 号：R735.2[医药卫生—肿瘤]