弓形虫抗体阳性精神分裂症一级亲属免疫球蛋白研究  

Study of the Level of Immunoglobulin in the First-degree Relatives of Schizophrenia Patients with Seropositivity to Toxoplasma gondii

作　　者：王德刚[1,2] 王高华[1] 王惠玲[1] 王波 许安荣 李新胜[2] 刘晓华[2] 雷香菊 

机构地区：[1]武汉大学人民医院精神卫生中心,武汉430060 [2]十堰市东风公司茅箭医院

出　　处：《数理医药学杂志》2009年第3期288-289,共2页Journal of Mathematical Medicine

基　　金：美国Stanley医学研究基金会资助项目(01T-435)

摘　　要：目的:了解弓形虫抗体阳性精神分裂症一级亲属免疫球蛋白的水平与正常人有无差异。方法:用速率散射比浊法检测弓形虫抗体阳性精神分裂症一级亲属免疫球蛋白(IgG、IgM)指标,并与弓形虫抗体阴性精神分裂症一级亲属、正常对照组进行比较。结果:弓形虫抗体阳性精神分裂症一级亲属免疫球蛋白明显高于两个对照组。结论:弓形虫感染可能是一种独立的发病因素,至少是一种诱发因素。Objective. To evaluate the concentration of immunoglobulin in the first-degree relatives of Schizophrenia Patients with Seropositivity to Toxoplasma gondii. Methods： The level of immunoglobulin G and M were measured with rate scatter turbid assays for the first-degree relatives of Schizophrenia Patients with Seropositivity to Toxoplasma gondii and the normal controls. Results. The concentration of hnmunoglobulin in the first-degree relatives of Schizophrenia patients with Seropositivity to Toxoplasma gondii was higher significantly than the control group. Conclusion There might be a causal relationship between toxoplasma gondii and the etiology of schizophrenia, or a inducement of schizophrenia at least.

关 键 词：弓形虫抗体 精神分裂症 一级亲属 免疫球蛋白 

分 类 号：R749.3[医药卫生—神经病学与精神病学]