Bmi-1基因与肿瘤关系研究进展  

Research advancement on relationship between Bmi-1 gene and tumor

作　　者：刘丹丹[1] 张艳丽[2] 孟秀香[1,2] 

机构地区：[1]大连医科大学诊断学实验中心,辽宁大连116044 [2]大连医科大学检验医学院,辽宁大连116044

出　　处：《大连医科大学学报》2009年第3期355-358,共4页Journal of Dalian Medical University

摘　　要：原癌基因Bmi-1属于转录抑制因子Polycomb(PcG)家族,通常作用于INK4a/ARF基因位点而影响细胞增殖及衰老。研究表明,多种成体干细胞和肿瘤干细胞的自我更新及增殖活性的维持也需要Bmi-1基因。Bmi-1基因的表达水平还与肿瘤的侵袭、转移、预后及复发有关,因而有望成为一种新的肿瘤分子标志物。Bmi- 1, a putative oneogene, belongs to the polycomb group family of transcriptional regulators, which usually affects cell proliferation and insenecenee through suppress of the INK4a/ARF locus. It not only supports the proliferation of several adult stem cells and tumor stem cells but also is required for the self - renewal ability of them. Recently researches have indicated that the expression level of Bmi - 1 is positively correlated to malignant tumor invasion, distant metastasis, prognosis and recurrence. It has prospective potential to be a valuable tumor molecule marker.

关 键 词：BMI-1 肿瘤干细胞 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]