耐受氟喹诺酮类药物真菌的筛选  

Isolation and Identification of Fungi with Tolerance to Fluoroquinolones

作　　者：高元钢[1] 向云彬[1] 余之焕 周全[2] 吴兴[1] 刘春垒[1] 余知和[1] 

机构地区：[1]长江大学生命科学学院,湖北荆州434025 [2]湖北省黄石市中医院,湖北黄石435000

出　　处：《长江大学学报（自科版）（中旬）》2009年第1期76-80,共5页Journal of Yangtze University(Nature Science Edition)

基　　金：湖北省教育厅青年项目(2004Q002);湖北省自然科学基金项目(2004ABA255)

摘　　要：从氟喹诺酮类药物(FQs)的污染土壤中筛选出37株真菌,其中2株真菌对氧氟沙星、诺氟沙星、盐酸左氧氟沙星和盐酸环丙沙星4种FQs的耐受浓度都可分别达到1800μg/mL,且能在同时含有这4种FQs浓度为1000μg/mL的培养基中生长。经初步鉴定,这2株真菌分别为杂色曲霉(Aspergillus versicolor)和黑曲霉(Aspergillus niger)。Fluoroquinolones are commonly used as antimicrobial agents, which have caused environmental pollution by over dosage.Microbiological biodegredation is an effective way of bioremedying the soil polluted by fluoroquinolones.Thirty-seven fungal strains were isolated from the FQs polluted soil,in which two of them were identified as Aspergillus versicolor and Aspergillus niger could endurate not only the highest concentrations of the four FQs up to 1 800 μg/mL,respectively,but also grow well in the media with four kinds of FQs with each concentration of 1 000 μg/mL.

关 键 词：氟喹诺酮类药物 真菌分离 耐受浓度 残留 土壤污染 

分 类 号：X172[环境科学与工程—环境科学]