后程加速超分割三维适形放射治疗食管癌临床观察  

Clinical efficacy analysis of late course accelerated and hyperfrationated three dimensional conformal radiotherapy for intem esophageal carcinoma

作　　者：仲荣达[1] 侯黎[2] 王继营[1] 杨正林[1] 

机构地区：[1]云南省第二人民医院,云南650021 [2]云南省第一人民医院

出　　处：《中国医学创新》2009年第16期6-7,共2页Medical Innovation of China

摘　　要：目的探讨后程加速超分割三维适形放射治疗（LCAH-3DCRT）中晚期食管癌的近期疗效。方法68例中晚期食管鳞癌随机分为后程加速超分割三维适形组34例（后超组）和后程三维适形组34例（对照组）。两组均先行常规放疗：2Gy／（次·d），剂量40Gy／4周；后超组后程采用加速超分割三维适形照射，1.5Gy／次，2次／d，间隔6h，全程剂量67.0-71.5Gy／38-41次，40-45d。对照组后程采用三维适形放疗，2Gy／（次·d），全程剂量66-70Gy／33-35次，45-50d。结果1、2、3年生存率后超组及对照组分别为85％（29／34）、68％（23／34）、56％（19／34）及62％（21／34）、41％（14／34）、32％（11／34）（P〈0.05），两组放疗副反应无明显差别。结论后程加速超分割三维适形放射治疗能明显提高食管痛患者1、2、3年生存率.不增加放疗副反麻及并发痒。Objective To evaluate the value of late course accelerated and hyperfraction three dimensional conformal radiotherapy （ LCAH - 3DCRT） for edinte - advanced esophageal carcinoma. Methods 68 patients with esophageal carcinoma were randomized into LCAF group（ observation group） and three dimensional conformal radiotherapy （3DCRT） group （control group）. Both of two groups recived DT 40Gy/4w by conventional fractionation radiotherapy （CFR）, 34 patients of LCAF group continued to receive late course accelerated and hypeffraction three dimensional conformal radiotherapy （ LCAH - 3DCRT）, DT = 1.5Gy 2t/d interfration six hours DT = 67.0-71.5 Gy/38- 41F/40-45d. 34 cases of 3DCRT group received DT = 66-70 Gy/33-35F/40-45d,2 Gy/d. Results The one, two and three - year survival rates were 85% （29/ 34） , 68% （23/34） ,56% （19/34）in LCAH - 3DCRT group and 62% （21/34） , 41% （14/34） , 32% （11/34） in 3DCRT group, respectively. There was no significant between tow groups about clinical radiotherapy symptoms. Conclusion The survival rates of patients with esophageal carcinoma can be improved by LACF-3DCRT without increasing any complication.

关 键 词：食管癌 三维适形放射治疗 后程加速超分割 

分 类 号：R730.55[医药卫生—肿瘤] R735.1[医药卫生—临床医学]