宫颈癌动脉化疗栓塞后微血管密度的变化  

The change of the expression of microvascular density after intra-arterial chemo-embolization in patients with cervical cancer

作　　者：阮晓红[1] 钟开运[1] 杨爱莲[1] 周伟[1] 茹景顺[1] 黎红[1] 

机构地区：[1]中山大学附属江门医院,广东江门529070

出　　处：《中国妇幼保健》2009年第16期2199-2201,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨选择性动脉化疗栓塞后宫颈癌组织微血管密度（Mierovessel density，MVD）的变化。方法：52例Ib2～IIb期原发性宫颈癌患者接受了选择性动脉化疗栓塞，根据患者的近期临床疗效分为有效组和无效组，分析两组动脉化疗栓塞前后肿瘤组织MVD的变化。结果：有效组和无效组选择性动脉化疗栓塞后MVD均较治疗前有所下降，有效组下降多于无效组，但有效组化疗栓塞后MVD与化疗栓塞前相比差异无统计学意义（P〉0．05）。结论：化疗栓塞后MVD可在一定程度上反映残留癌组织的血供和细胞活性，其可能受多种因素的影响。如缩短介入化疗的间歇时间及化疗栓塞后手术的时间可能提高疗效，如在动脉栓塞时配伍抗微血管生成的药物有可能提高疗效。Objective： To explore the change of the expression of microvessel density （MVD） of tumor tissue in patients with cer- vical cancer after selective intra - arterial chemo - embolization. Methods ： 52 women with primary cervical cancer in stage Ib2 - II b accord- ing to the FIGO classification received selective intra - arterial chemo - embolization. They were divided into the effective group and non - effective group according to the clinical response to the treatment. The MVDs were detected before and after treatment. Results： A decrease was found in MVD after chemoembolization especially in effective group, but without significance （ P 〉 0.05 ） . Conclusion： MVD after in- traarterial chemo - embolization shows the angiogenesis and activities of the remain cancer cells, which may be affected by many factors. The curative effect can be improved by shortening the duration of the endovascular intervention chemotherapy and combining angiogenesis inhibitors.

关 键 词：子宫颈癌 动脉化疗 化疗栓塞 微血管密度 

分 类 号：R737.33[医药卫生—肿瘤]