口服扎来普隆对大学生睡眠剥夺后任务管理功能的影响  

Effects of administration of zaleplon on task management functions of students after the depriving sleep

作　　者：齐建林[1] 邵永聪[3] 杨征[2] 苗丹民[3] 毕国华[2] 

机构地区：[1]空军总医院临床心理科,北京100036 [2]军事医学科学院基础医学研究所 [3]第四军医大学航空航天医学系心理学教研室

出　　处：《中华行为医学与脑科学杂志》2009年第3期263-265,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：全军“十一”五医药卫生科研基金（062066）

摘　　要：目的探讨口服10mg扎来普隆5h后其残留镇静效应对任务管理功能的影响。方法对9名健康大学生进行43h的完全睡眠剥夺，而后随机服用安慰剂或10mg扎来普隆，进行4h的恢复性睡眠。被试分别在睡眠剥夺1h（基线值）、24h和恢复性睡眠后1h分别完成一次连续加法测验。记录正确数和平均正确反应时，采用重复测量的统计方法分析数据。结果连续加法测验在基线值、24h完全睡眠剥夺和恢复性睡眠1h后的平均正确反应时间存在时间主效应（F（2,16）=10．46，P〈0．01），同时正确数也存在时间主效应（f=16）=5．30，P〈0．05），进一步分析24h完全睡眠剥夺时的平均正确反应时[（14．67±2．91）s]较基线值[（12．98±2．52）S，P〈0．01]和恢复性睡眠1h后[（13．19±2．30）s]延长（P〈0．01），正确数[（14．22±2．70）个]较基线值[（16．25±2．33）个]（P〈0．05）和恢复性睡眠1h后[（16．09±2．23）个]减少（P〈0．05）。而在安慰剂与扎来普隆间差异无显著性（P〉0．05）。结论任务管理功能在24h完全睡眠剥夺后已明显受损；在口服10mg扎来普隆5h后其残留镇静效应已对任务管理功能已没有影响。Objective To investigate effects of single-dose administration of zaleplon 10 mg on task management functions. Methods 9 healthy undergraduate students were tested three times during a period of 43 h of total sleep deprivation（TSD） in a serial plus test ： the first at 7：00 AM （ 1 h after the beginning of TSD, the baseline） ,the second at 1：00 AM on the second day （24 h TSD）, the third at 7：00 AM 1 h after recovery sleep （ 1 h following RS）. Mean correct reaction time and correct numbers were recorded. Repeated measures ANOVA were also performed for analysis of data. Results There was the main effect of mean correct reaction times of the serial plus test among baseline,24 h TSD and 1 h following RS（F（2,16） = 10.46, P 〈 0.01 ） and this was due to the mean correct reaction times of 24 h TSD （ 14.67 ± 2.91 ） s were longer than that of baseline（ 12.98±2.52） s（P〈0.01 ） and 1 h following RS（ 13.19 ± 2.30 ） s （P 〈 0.01 ）. Correct numbers of the serial plus test have the same main effect （F（2,16）=5.30, P〈0.05 ）. The correct numbers of 24 h TSD （ 14.22±2.70 ） were more than that of baseline （ 16.25±2.33 ） （P 〈 0.05 ） and 1 h following RS（ 16.09±2.23 ） （P 〈 0.05 ）. However, there were no differences on the performance of the test between the placebo group and the zaleplon group （P〉0.05 ）. Conclusion Task management functions of the executive function are already impaired significant after 24 h of TSD, Residual sedation of zaleplon has no influences on the task management functions after 5 h after single-dose administration of one 10 mg.

关 键 词：扎来普隆 任务管理功能 完全睡眠剥夺 恢复性睡眠 

分 类 号：R74[医药卫生—神经病学与精神病学]