棕色田鼠性别决定研究进展  

Recent advances on sex determining mechanisms of Microtus mandarinus

作　　者：闫楠[1] 朱必才[1] 王宇峰[1] 

机构地区：[1]徐州师范大学生命科学学院,徐州221116

出　　处：《遗传》2009年第6期587-594,共8页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:30470966;30270738)资助

摘　　要：哺乳动物性别决定方式属于雄性异配型性别决定,依赖于Y染色体,SRY基因是性别决定中最重要的基因。文章报道了棕色田鼠指名亚种有Y染色体,但是Y染色体上没有SRY基因,性别决定不依赖于SRY基因,排除了R-spondin1基因是性别决定基因,同时讨论了棕色田鼠指名亚种SRY基因缺失后可能的性别决定机制。Most mammalian sex determination belongs to male heterogametic type of genetic sex determination. Sex determination of most mammals depends on the Y chromosome. SRY gene is the testis-determining factor on Y chromosome of most mammals, which is thought to be the most important gene in sex determination by far. Recent studies on Microtus mandarinus mandarinus demonstrated that the subspecies has Y chromosome, but there is no SRY gene on Y chromosome. Sex determination of Microtus mandarinus mandarinus is independent of SRY gene. R-spondinl has also been excluded as the sex determination gene of Microtus mandarinus mandarinus. This paper reviews recent advances on sex determining mechanisms of Microtus mandarinus mandarinus. Possible sex determining mechanisms of Microtus mandarinus man- darinus in the absence of SRY gene are also discussed.

关 键 词：棕色田鼠 SRY基因 性别决定 

分 类 号：Q3[生物学—遗传学]