儿童NHL淋巴瘤细胞白血病的临床病理研究  

Clinicopathologic Study of Lymphoma Cell Leukemia of Childern′s Non Hodgkin Lymphoma

作　　者：王可欣[1,2] 苏琦[1,2] 周秀田[1,2] 沈建军[1,2] 李一琴[1,2] 

机构地区：[1]衡阳医学院第二附属医院 [2]衡阳医学院肿瘤研究所

出　　处：《衡阳医学院学报》1998年第2期168-170,共3页

摘　　要：本文报告１１例儿童非何杰金氏淋巴瘤并发淋巴瘤细胞白血病（ＬＣＬ），其中，裂、无裂细胞性３例，无裂细胞性４例，淋巴母细胞性４例；临床Ⅲ期７例，Ⅳ期４例；局部淋巴结迅速增大９例，全身浅表淋巴结肿大７例，腹部肿块４例，纵膈肿块３例，肝肿大１０例，脾肿大６例，发热、消瘦各９例，苍白１０例，血红蛋白、血小板低于正常值各１０例，白细胞高于正常值８例，骨髓象增生活跃，原始或幼稚淋巴细胞０．２５～０．８０，平均０．３９。经ＶＰ、ＶＣＰ方案治疗２～８个疗程，ＣＲ２例，ＰＲ６例，ＮＲ２例，近期有效率８０％，诊断后生存４天～１６个月，提示ＮＨＬ发生ＬＣＬ后，病情严重，远期疗效不佳，预后差，短期内便导致死亡。Clinicopathologic features of 11 cases of lymphoma cell leukemia(LCL) in childern′s non Hodgkin lymphoma were studied.There were 3 cases of cleaved noncleaved,4 cases of non cleaved and 4 cases of lymphoblastoma;stage Ⅲ7 cases and Ⅳ4 cases;9 cases of quickly local lymphadenopathy,7 cases of system superficial lymphadenopathy,4 cases of abdominal mass,3 cases of mediastinal mass,10 cases of liver enlargement,7 cases of splenomegaly,9 cases of fever and weight loss,8 cases of marked elevation of WBC count,10 cases of decrease of Hb and thrombocyte count;and blast or immature lymphocyte 0.25～0.80 in bone marrow aspirates.There were CR 2 cases,PR 6 cases and NR 2 cases after treated by VP or VCP,survive 4 days to 16 months after diagnosis.It suggested that LCL were critical condition,rapid advance,poor treated effect and severe prognosis.

关 键 词：儿童 非何杰金淋巴瘤 淋巴瘤细胞 白血病 病理 

分 类 号：R733.702[医药卫生—肿瘤]