肝硬化患者血浆ET_1、CGRP变化意义探讨  

Exploration on signifficance of alterations of plasma ET 1 and CGRP leves in patient with liver cirrhosis

作　　者：王子强[1,2] 徐章[1,2] 卡旭鹏[1,2] 张兵 张洁琴[1,2] 

机构地区：[1]东风汽车公司中心医院消化科 [2]郧阳医学院东风临床学院

出　　处：《胃肠病学和肝病学杂志》1998年第2期139-140,144,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的：为了解ＬＣ患者血浆ＥＴ、ＣＧＲＰ水平，探讨其临床意义。方法：采用放射免疫分析法检测健康成人及ＬＣ患者血浆ＥＴ、ＣＧＲＰ水平。结果：ＬＣ组血浆ＥＴ１明显高于对照组（Ｐ＜０．０１），ＣＧＲＰ明显低于对照组（Ｐ＜０．０１）。ＬＣ组内ＥＴ１、ＣＧＲＰ水平与肝功分级、血浆蛋白及ＡＬＴ、ＡＳＴ值无明显相关性（Ｐ＞０．０５）。结论：作为血管活性物质ＥＴ与ＣＧＲＰ相互拮抗，调节门脉压力保持动态平衡。ＬＣ门脉高压的形成和发展与ＥＴ升高、ＣＧＲＰ下降有关。探讨二者之间的关系将有助于加深对ＬＣ及其并发症的认识。Aim: For understanding the plasma ET 1 and CGRP levels in patient with liver cirrhosis (LC) its clinical signifficance was explored Methods:Plasma ET 1 and CGRP levels were determined by radioimmunoussay in healthy adults and patient with liver cirrhosis.Results:Plasma ET 1 levels were signifficantly higher in patient group than in control group (P<0.01),and plasma CGRP levels were markedly lower in patients group than in control group (P<0.01),Plasma ET 1 and CGRP levels in LC group were not obviously correlated with classification of liver function, plasma protein and values of ALT and AST(P>0.05) Conclusion:The ET 1 and CGRP that are used as vasoactive substance contrarily regulate each other and vemain dynamic equilibrium of portal vein pressure The production and development of LC are related to the increase of ET 1 and decrease of CGRP. To explore the relation between them will be thelpful to strengthening recognitions of LC and its complication, and exploring new drugs of the reducing portal vein pressure.

关 键 词：肝硬化 内皮素 CGRP 病理 

分 类 号：R575.202[医药卫生—消化系统]