下咽癌EGFR、NM23、Bcl-2基因表达与临床意义  

Expressions of EGFR,NM23 and BCL-2 in hypopharyngeal cancer and their clinical significance

作　　者：杨秋安[1] 杨金霞[1] 付卫江[1] 张廷国[2] 王妍[2] 刘文君[2] 章晓梅[1] 赵维萍[1] 

机构地区：[1]山东大学齐鲁医院肿瘤中心,济南250012 [2]山东大学齐鲁医院病理科,济南250012

出　　处：《山东大学学报（医学版）》2009年第4期109-113,共5页Journal of Shandong University:Health Sciences

摘　　要：目的研究EGFR、NM23和Bcl-2基因在下咽鳞状细胞癌组织中的表达规律及与下咽癌临床病理因素的关系,评价其在临床应用的价值。方法下咽癌29例手术后石蜡包埋组织,制作切片,用免疫组化SP法检测EGFR、NM23和Bcl-2基因的表达,分析它们与下咽癌临床病理因素之间的相关关系。结果EGFR、NM23和Bcl-2的阳性表达率,分别为62%(18/29)、79%(23/29)和86%(25/29)。EGFR在低分化癌组的阳性表达率高于高中分化组(P=0.021),在淋巴结转移组的阳性表达率明显高于无淋巴结转移组(P=0.018)。NM23和Bcl-2与临床病理因素无关。结论EGFR在下咽癌的高表达与分化及淋巴结转移密切相关,可以作为辅助判断下咽癌临床特性的生物学指标。NM23和Bcl-2表达的规律,有待进一步研究。Objective To investigate expressions of EGFR, NM23 and Bcl-2 in hypopharyngeal cancer and their correlation with elinicopathologieal risks. Methods Expressions EGFR, NM23 and Bel-2 in 29 cases of hypopharyngeal cancer were determined with an immunohistochemical S-P method. Results Expressions of EGFR, NM23 and Bcl-2 in hypopharyngeal cancer were 62% （18/29）, 79% （23/29） and 86% （25/29） respectively. The EGFR level in poorly differentiated cancer was significantly higher than that in well or moderately differentiated cancer （ P = 0.021）, and the EGFR level in the group with unilateral and bi- lateral lymph node metastases was significantly higher than that in the group without lymph node metastases （P = 0.018）. How-ever, expressions of NM23 and Bcl-2 had no correlation with clinicopathologieal changes. Conclusion Expression of EFGR is correlated with pathological differentiation and lymph node metastasis, and EFGR may be a potential hiomarker for assessing hy- popharyngeal cancer. NM23 and Bcl-2 need to be further warranted.

关 键 词：下咽肿瘤 表皮生长因子受体 NM23 B细胞淋巴瘤基因2 

分 类 号：R739.63[医药卫生—肿瘤]