大剂量甲氨蝶呤在白血病患者中的药物动力学研究  

Pharmacokinetics of high-dose Methotrexate in leucocythemia patients

作　　者：任立霞 颜怀城[2] 谢军[2] 李传波 

机构地区：[1]解放军第五一三医院药剂科,甘肃兰州732750 [2]第三军医大学学员旅,重庆400038

出　　处：《中国医药导报》2009年第16期31-32,共2页China Medical Herald

摘　　要：目的:用荧光偏振免疫分析法测定白血病患者血清中甲氨蝶呤的浓度。方法:对5例白血病患者静滴大剂量甲氨蝶呤(1000mg)的药物动力学进行研究。结果:分布半衰期(t1/2α)为(1.63±0.23)h,β相消除半衰期(t1/2β)为(12.8±2.4)h,速率常数(K10)为(0.41±0.05)/h,表观分布容积(Vc)为(17±5)L,总清除率(Cls)为(6.8±1.3)L/h,药时曲线下面积(AUC)为(334±61)μmol·h/L,其经时血药浓度符合二室开放模型。结论:结果可靠,与文献报道一致,可用于临床用药参考。Objective： To measure the serum concentration of Methotrexate with fluorescence polarization immunoassay. Methods： The pharmacokinetics of five leucocythemia patients received high-dose Methotrexate （1 000 mg） were studied. Results： t1/2α was （1.63±0.23） h, t1/2β was （12.8±2.4） h, K10 was （0.41±0.05）/h, Vc was （17±5） L, Cls was （6.8±1.3） L/h, AUC was （334±61）μmol·h/L, and its blood concentration was consistent with the two-compartment open model. Conclusion： The results is credible and consistent with reported literatures, and can be used as a reference in clinic.

关 键 词：甲氨蝶呤 药物动力学 白血病 

分 类 号：R733.7[医药卫生—肿瘤]