缺血预处理对大鼠脑钙调神经磷酸酶活性的影响  

Effects of ischemic preconditioning on the activity of calcineurin in the brain of rat

作　　者：郑梅[1] 张敏[2] 朱宁[1] 张纬[1] 孙晓明[1] 于公元[1] 

机构地区：[1]天津医科大学生化教研室,天津300070 [2]武警医学院生化教研室,天津300162

出　　处：《武警医学院学报》2009年第5期380-381,414,共3页Acta Academiae Medicinae CPAPF

基　　金：天津市教育委员会科研基金项目(200011)

摘　　要：【目的】观察脑缺血和缺血预处理对大鼠脑钙调神经磷酸酶(CaN)活性的影响,探讨CaN在脑缺血中的作用。【方法】制备大鼠大脑缺血及缺血预处理模型,分步离心提取蛋白,应用紫外分光光度法测定各组CaN在大鼠脑中的活性。【结果】缺血组CaN活性明显低于正常组(P<0.05),缺血预处理组CaN活性明显高于缺血组(P<0.05)。【结论】实验结果表明缺血预处理可保护大鼠脑缺血时CaN的活性。[ Objective] To observe the effects of ischemic preconditioning on the activity of calcineurin in the brain of rat. [Methods] Focal cerebral ischemia and cerebral ischemia preconditioning in normal rats were induced. The activity of calcineurin in each group was examined. [ Results] The activity of calcineurin in cerebral ischemia group was significantly lower than that in control group （ P 〈 0.05）. [ Conclusions] These results suggest that the activity of calcineurin in cerebral ischemia is protected by ischemic preconditioning.

关 键 词：缺血预处理 钙调神经磷酸酶 脑 

分 类 号：R331.3[医药卫生—人体生理学]