表观遗传修饰对转基因和克隆胚早期发育的影响研究进展  

Advancement of Epigenetic Modifications Regulate Influences Transgenic and the early Development of Cloned Embryo

作　　者：张进荣 马晶晶[2] 

机构地区：[1]咸阳市秦都区农村能源办公室,陕西咸阳712001 [2]西北农林科技大学动物医学院,陕西杨凌712100

出　　处：《中国牛业科学》2009年第3期32-36,91,共6页China Cattle Science

摘　　要：表观遗传修饰在基因表达和克隆胚的早期发育方面有重要作用。本文从DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA调控方面综述了表观遗传的发生机制及其对转基因和克隆胚早期发育的影响。该文对表观遗传的研究有重要的指导作用。Epigenetic modifications plays an important role in gene expression and the early development of cloned embryo. From four aspects including DNA methylation, histone acetylation, chromatin remodeling and non-coding RNAs, this article discribed the mechanism of epigenetic modifications and its effects on transgene and the early development of cloned embryo. The article has great instructional significants for researching epigenetic modifications.

关 键 词：表观遗传修饰 DNA甲基化 组蛋白修饰 基因印记 核重编程 

分 类 号：S823.2[农业科学—畜牧学]