caveolin-1和pERK1/2在甲状腺乳头状癌中的表达及意义  

Expression and Significance of caveolin-1 and pERK1/2 in Papillary Carcinoma of Thyroid

作　　者：刘雅林[1] 刘宏侠[2] 

机构地区：[1]武警北京市消防总队医院,北京100035 [2]河北唐山市协和医院病理科

出　　处：《实用预防医学》2009年第3期692-695,共4页Practical Preventive Medicine

摘　　要：目的探讨甲状腺乳头状癌中caveolin-1(cav-1)与pERK1/2的表达及其意义。方法采用免疫组织化学法,检测40例甲状腺乳头状癌、11例甲状腺腺瘤及10例癌旁正常甲状腺组织中cav-1和pERK1/2的表达,并分析表达情况与临床病理参数之间的关系。结果cav-1在甲状腺腺瘤和癌旁甲状腺组织中为低表达或无表达,而在甲状腺乳头状癌中呈高表达(阳性率为60%),且与肿瘤的包膜浸润和淋巴结转移相关。pERK1/2在甲状腺乳头状癌、甲状腺腺瘤和癌旁甲状腺组织中均见表达,三者差异无统计学意义。cav-1和pERK1/2两者之间的表达无相关性。结论cav-1高表达可能参与调控甲状腺乳头状癌的进展和转移,可作为预后不良的指标。Objective To investigate the expression and significance of caveolin - 1 （cav- 1） and pERK1/2 in papillary carcinoma of thyroid. Methods The expression of cav - 1 and pERK1/2 proteins was assessed by immunohistochemical method in 40 cases of papillary carcinoma of thyroid, 11 cases of follicular adenoma and 10 cases of normal thyroid tissues ad- jacent to carcinoma. The relationship between the expression of these proteins and clinicopathological parameters was exam- ined. Results cav- 1 showed low or no expression in adenoma or normal thyroid tissues adjacent to carcinoma. In cont- rast, expression of cav- 1 was much higher in papillary carcinoma （with the positive rate of 60% ） and the abnormal expres- sion was related to capsule invasion and lymph node metastasis. Expression of pERK1/2 was detected in papillary carcinoma, follicular adenoma as well as normal thyroid tissues adjacent to carcinoma. However, the difference was not significant. There was no correlation between cav- 1 and pERK1/2 expression in papillary carcinoma. Conclusions cav- 1 was over - ex- pressed in papillary carcinoma of thyroid. The abnormal expression of cav 1 may be involved in the regulation of tumor pro- gression and metastasis, which suggests that cav- 1 could serve as an indicator of poor prognosis in papillary carcinoma of thyroid.

关 键 词：甲状腺乳头状癌 窖蛋白-1 细胞外信号调节激酶 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]