胃炎患者的胃动力功能评价  

Research Gastric Motility for Erosive Gastritis

作　　者：刘圣蓉[1] 李章勇[1] 任超世[1] 刘纯伦[2] 方晓杰[2] 

机构地区：[1]重庆邮电大学生物医学工程研究中心,重庆400065 [2]重庆医科大学附属第一医院消化内科,重庆400014

出　　处：《中国医学物理学杂志》2009年第3期1224-1227,1248,共5页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(No.60471041);重庆市教委科技项目(No.KJ080519)

摘　　要：目的:研究糜烂性胃炎患者胃动力系统的复杂电过程和运动机理,包括它的节律、传导、胃排空过程以及影响它们的因素,提取和分析表达糜烂性胃炎的胃动力特征参数。方法:按照临床判断标准筛选30例糜烂性胃炎患者,信号检测设备和处理软件系统由重庆邮电大学研制。从体表提取的胃阻抗信号和胃电运用小波多分辨分析处理将胃阻抗信号从呼吸和血流信号中分离出来。用能谱和频谱分析方法,根据主能量和支配频率将信号分类。胃电信号和胃阻抗信号的频率、功率谱、动态谱、节律大小、正常胃电和胃阻抗节律的功率等参数由该系统提供。结果:患者的胃动力测量和评估的实验表明患者与正常人群的胃动力参数都具有显著性差异(P<0.05);用药一周后,患者主观症状还没有消除或者缓解,但是患者胃电功率和频率变异系数有显著性变化(P<0.05),来源于阻抗信号的胃动力参数没有显著性变化(P>0.05)。结论:实验结果表明基于阻抗和同步胃电测量的综合应用可能提供一种无创的技术来研究和估计与胃肠生理学和病理学情况一致的胃动力状况。Objective： In order to investigate the complex course of electricity and mechanism of erosive gastritis （EG）, including its rhythm, transmission, gastric empty course and the influences of them, it is neccesery to extract gastric motility feature indexes. Methods： According the clinic standardization, 30 volunteers of erosive gastritis were selected. The signal processing device was designed by Chongqing University of Posts and Telecommunications. Both signals impedance gastric motility （IGM） and EGG collected from body surface are decomposed by Multi-resolution Analysis （MRA）. Wavelet transform is addressed te separate the IGM signal from breathing and blood flowing impedance signals. By the means of energy and freqency spectrum analysis technic, the signals can be classify according to the dominant power and dominant frequency. Some indexes such as frequency of EGG and IGM, signal power spectrum and dynamic spectrum, the rates of rhythm and power for the normal EGG and IGM and so on can also be calculated. Results： The experiments of gastric motility measurement and evaluation are executed including before tearing and after a week. The parameters have changed signifcantly between health adult and patient （P〈0.05）. The volunteers feel that the symptom is not disappeared. The feature of electrogastrogram has changed significantly （such as power instability coefficient, fi＇equency instability coefficient P〈0.05）, otherwise those of impedance signal has not （P〉0.05）. Conclusion： The results of the experiments show that the method based on the synchronous measurement of EGG and IGM can provide a non-invasive way to investigate and evaluate gastric motility situation corresponding gastrointestinal physiology and pathology conditions.

关 键 词：糜烂性胃炎 胃阻抗 多分辨分析 胃慢波 无创 

分 类 号：R318[医药卫生—生物医学工程]