伴代谢综合征的高血压病患者动脉功能的变化  

Changes of the Arterial Function in Essential Hypertensive Patients with Metabolic Syndrome

作　　者：郑建清[1] 周亦卿[2] 林金秀[2] 

机构地区：[1]福建医科大学附属第一医院急诊科,福建省福州市350005 [2]福建医科大学附属第一医院心内科,福建省福州市350005

出　　处：《中国动脉硬化杂志》2009年第4期315-317,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨伴有代谢综合征的高血压病患者动脉功能的变化。方法64例门诊高血压病患者分为高血压病合并代谢综合征组(简称为伴代谢综合征组,32例)和单纯高血压病组(32例),31例健康受试者作为对照组,检测受检者的肱-踝脉搏波传导速度、大动脉弹性和小动脉弹性。比较三组受试者肱-踝脉搏波传导速度、大动脉弹性和小动脉弹性变化,分析动脉功能与各危险因素的相关性。结果与对照组(1517.9±315.0cm/s)相比,伴代谢综合征组(1916.5±318.0cm/s)和单纯高血压病组(1757.6±313.9cm/s)肱-踝脉搏波传导速度均显著增加(P<0.01和0.05),且伴代谢综合征组显著高于单纯高血压病组(P<0.05)。对照组、单纯高血压病组和伴代谢综合征组受试者大动脉弹性(113.2±46.2、91.1±35.0和66.6±31.1mL/mmHg,P<0.01)和小动脉弹性(505±244、355±195和253±116mL/mmHg,P<0.05)依次降低。Peason相关分析表明肱-踝脉搏波传导速度与年龄、收缩压、脉压差、甘油三酯呈显著正相关(P<0.01),与高密度脂蛋白胆固醇呈显著负相关(P<0.01);大动脉弹性、小动脉弹性与高密度脂蛋白胆固醇呈正相关(P<0.05和0.01),而与年龄、收缩压、脉压差和甘油三酯呈负相关(P均<0.01)。结论代谢综合征加重高血压病患者动脉功能的减退。Aim To evaluate the changes of the arterial function in essential hypertensive （EH） patients with metabolic syndrome （MS）. Methods 64 patients with EH were assigned into two groups： EH with MS group （ n = 32 ）, EH without MS group （ n = 32 ）. 31 healthy subjects were served as normal control. Brachial-ankle pulse wave velocity （BaPWV） was measured using an automatic device （VP1000）, arterial elastic index （C1-large artery and C2-small artery ） were measured by the CVProfiler-2020 pulse wave analysis instrument. Results BaPWV in EH with MS group （1 916.5±318.0 cm/s） and EH without MS group （1757.6±313.9 cm/s） were higher than that in control group （1517.9±315.0 cm/s, P 〈0.01 and 〈0.05） ; and BaPWV in EH with MS group was higher than that in EH without MS group （ P 〈 0.05 ）. The magnitude of C1 and C2 reduced in proper order in control group, EH without MS group, EH with MS group （ C1： 113.2±46.2, 91.1± 35.0 and 66.6±31.1 mL/mmHg, P〈0.01 ; C2 ： 505±244, 355±195 and 253±116 mL/mm Hg, P 〈0.05）. Pearson correlation showed that BaPWV was positively related with age, systolic blood pressure, pulse pressure difference and triglyceride （P〈0.01） , negatively related with high density lipoprotein cholesterol （HDLC）（ P〈 0.01） ; C1 and C2 were positively related with HDLC （ P 〈 0.05 and 0.01）, and negatively related with age, systolic blood pressure, pulse pressure difference and triglyceride （P〈0.01）. Conclusion MS may aggravate the dysfunction of artery in EH patients.

关 键 词：高血压病 代谢综合征 肱-踝脉搏波传导速度 动脉弹性 

分 类 号：R363[医药卫生—病理学]