衰老脑组织的电镜对比观察  

Pathological changes of aging brain by electronmicroscope

作　　者：赵继宗[1,2] 孙异临[1,2] 任泽光[1,2] 曲宝清 

机构地区：[1]北京天坛医院神经外科 [2]北京市神经外科研究所

出　　处：《中华神经外科杂志》1998年第2期101-103,共3页Chinese Journal of Neurosurgery

摘　　要：目的：了解神经系统衰老的一些特征性变化。方法：对取自不同年龄组动静脉畸形或动脉瘤病人的脑皮层标本进行了电镜检查。结果：在老年组，神经元固缩、核糖体解聚、胞浆内出现大量脂滴及脂褐素颗粒、染色质凝聚。胶质细胞胞体及突起肿胀、胞浆空化、突触减少、轴索内神经微丝溶解。Objective: To investigate the characteristic pathological changes of the aging brain. Methods: Electronmicroscopic examination on cerebral cortex derived from patients with AVM or aneurysm. Results: For the neuron, we can find pyknosis of neuron, depolymerization of ribosome, accumulation of lipid droplets and lipofuscin, condensation of chromatin. For the glia cell, there are swelling of body and process, cavitation of cytoplasm, decrease of synapses, dissolution of filament in axon. Conclusion: The changes of aging brain is similar to that of Alzheimer's disease.

关 键 词：脑衰老 电镜 病理 脑动静脉畸形 

分 类 号：R743.402[医药卫生—神经病学与精神病学]