泮托拉唑杂质的合成研究  

Synthesis of the impurity of pantoprazole

作　　者：陈帅[1] 李薇[1] 童元峰[1] 郝玲花[1] 吴松[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《中国新药杂志》2009年第10期940-941,共2页Chinese Journal of New Drugs

基　　金：卫生公益性行业科研专项经费资助(200802038)

摘　　要：目的:合成泮托拉唑合成中产生的杂质。方法:以5-二氟甲氧基-2-巯基-1H-苯并咪唑和2-氯甲基-3,4-二甲氧基吡啶盐酸盐(Ⅲ)为原料,经缩合,氧化,两步反应合成泮托拉唑砜及泮托拉唑砜氮氧化物。结果:最后化合物经核磁共振谱、质谱确证。结论:本路线合成的化合物可作为泮托拉唑质量控制中的杂质对照品,从而对杂质进行准确的定性、定量控制。Objective： To synthesize the impurity of pantoprazole as a reference substance. Methods：The sulfone of pantoprazole and its N-oxide were synthesized from 5-difluoromethoxy-2-mercapto-1H-benzimi-dazole and 2-chloromethyl-3, 4-dimethoxypydine through condensation and oxidation. Results： The structure was verified by ^1H-NMR and MS. Conclusion ：The synthesized compounds can be used as the reference substance of the impurity, so the impurity can exactly be controlled qualitively and quantitively.

关 键 词：泮托拉唑 合成 杂质 

分 类 号：R914.5[医药卫生—药物化学]