原发性肝细胞癌综合介入治疗的临床疗效  

Therapeutic effect of interventional treatments of hepatocellular carcinoma

作　　者：段训柏[1] 陈德基[1] 何明基[1] 申刚[1] 李汉文[1] 王广宇[1] 

机构地区：[1]广州医学院第二附属医院放射科,广东广州510260

出　　处：《中国介入影像与治疗学》2009年第3期240-244,共5页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的评价不同介入治疗方法综合治疗肝细胞癌(HCC)的临床疗效。方法原发性HCC患者113例,分4组:单纯肝动脉化疗栓塞术(TACE)组48例,TACE+射频消融术(RFA)组23例,TACE+表阿霉素(EPI)+碘油(LP)组33例,TACE+经皮注射无水乙醇(PEI)组9例。以术后1个月、3个月CT平扫及增强扫描肿瘤缩小率、甲胎蛋白(AFP)下降50%的比例、1年、2年生存率评估治疗效果。结果TACE+RFA组肿瘤缩小率、AFP下降50%比例均明显优于其他组,差异有统计学意义。1年及2年生存率各组间差异无统计学意义。结论TACE+RFA是中晚期原发性HCC患者的首选治疗方法。Objective To evaluate the clinical efficacy of different interventional therapies in the treatments of primary hepatocellular carcinoma （HCC）. Methods A total of 113 patiens with primary HCC were treated with different interventional theraries. The patients were divided into TACE group （48 cases）, TACE＋RFA group （23 cases）, TACE＋EPI＋ LP group （33 cases） and TACE＋PEI group （9 cases）. The therapeutic effects were then evaluated by the tumor shrinking rates observed with enhanced CT scaning after one month and 3 months respectively, the percentage of patients whose AFP level reduced by 50%, as well as 1 year and 2 years survival rates. Results In the TACE＋RFA group, the rates of tumor shrinking, the percentage of patients whose AFP levels reduced by 50%, 1 year and 2 years survival rates were all higher than those of other groups. Conclusion The combined therapy of TACE-~RFA should be the first choice for treatment of primary HCC.

关 键 词：肝动脉化疗栓塞术 癌 肝细胞性 介入治疗 

分 类 号：R735.7[医药卫生—肿瘤]