Tiam-1和Flt-4在甲状腺乳头状癌中的表达及意义  

Expression of Tiam-1 and Flt-4 in thyroid papillary carcinomas

作　　者：莫祥兰[1] 黄振录[1] 周祥祯[1] 丁志敏[1] 韦荣干[1] 

机构地区：[1]广西壮族自治区人民医院病理科,南宁530021

出　　处：《广东医学》2009年第6期894-896,共3页Guangdong Medical Journal

基　　金：广西壮族自治区科技厅自然基金资助(编号:桂科自0542062)

摘　　要：目的探讨T淋巴瘤侵袭转移基因(Tiam-1)和fms样酪氨酸激酶4(Flt-4)在甲状腺乳头状癌和正常甲状腺以及腺瘤组织中的表达情况,研究其在甲状腺乳头状癌发生和发展中的作用。方法用免疫组织化学方法检测102例甲状腺乳头状癌和100例正常甲状腺、11例腺瘤组织Tiam-1和Flt-4表达情况,分析其在甲状腺乳头状癌中的表达水平与临床特点关系。结果甲状腺乳头状癌Tiam-1和Flt-4表达水平升高,表达强度均与淋巴道转移有关(P<0.01);而正常甲状腺和腺瘤组织Tiam-1和Flt-4呈阴性或弱阳性表达;Tiam-1和Flt-4表达呈正相关性。结论甲状腺乳头状癌Tiam-1和Flt-4表达上调,抑制它们的表达可能可防治甲状腺乳头状癌的发生。Objective To investigate the expression of Tiam - 1 （ T lymphoma invasion and metastasis） and Fit - 4 （fms like tyrosine kinase 4） proteins in thyroid papillary carcinomas and their roles in the development of thyroid carcinoma. Methods The expression of Tiam - 1 and Flt- 4 was exmamined by immunohistochemistry in 102 cases of thyroid papillary carcinomas, 100 case of normal thyroid tissues and 11 cases of thyroid adenomas and was correlated with clinical features. Results The expression levels of Tiam - 1 and Fit - 4 proteins in thyroid papillary carcinoma were significantly higher than those in normal thyroid tissues and thyroid adenomas, and were correlated with lymph node metastasis. There was positive correlation between the expression of Tiam - 1 and Fit - 4 proteins. Conclusion Tiara - 1 and Fit - 4 may play an important role in the development of thyroid papillary carcinoma. Suppressing Tiara - 1 and Fit - 4 genes expression may prevent thyroid tumorigenesis.

关 键 词：甲状腺乳头状癌 T淋巴瘤侵袭转移基因 fms样酪氨酸激酶4 

分 类 号：R736.1[医药卫生—肿瘤] R73-37[医药卫生—临床医学]