CD44V6在表皮肿瘤及恶性黑素瘤的表达  

Expression of CD44V6 in Human Epidermal Tumours and Malignant Melanoma

作　　者：陈秀琴[1] 徐前喜[1] 林文玉[2] 李荣[1] 朱铁君[1] 

机构地区：[1]北京医科大学人民医院皮肤科,100044 [2]北京医科大学人民医院中心实验室,100044

出　　处：《中华皮肤科杂志》1998年第3期176-177,共2页Chinese Journal of Dermatology

摘　　要：目的　研究CD44V6在鳞状细胞癌、基底细胞癌和恶性黑素瘤的表达。方法　免疫组织化学对石蜡包埋组织标本进行检测。结果　 1 0例鳞状细胞癌CD44V6膜表达阳性 ,且随癌细胞分化程度降低CD44V6表达下调。 1 0例基底细胞癌和 8例恶性黑素瘤不表达CD44V6。Objective To study the expression of CD44V6 in human epidermal tumours and malignant melanoma. Methods The expression of CD44V6 was detected by an immunohistochemical technique in squamous cell carcinoma(SCC), basal cell carcinoma(BCC) and malignant melanoma(MM). Results CD44V6 was expressed on the membrane of tumour cells of 10 patients with SCC, and there was downregulation of CD44V6 expression which along with the decrease of differentiation of SCC tumour cells. Tumour cells of 8 patients with MM and 10 patients with BCC did not express CD44V6. Conclusion Our findings suggest that CD44V6 expression is correlated with the types of skin tumours.

关 键 词：CD44V6 鳞状细胞瘤 基底细胞瘤 黑素瘤 

分 类 号：R739.502[医药卫生—肿瘤]