脑动脉支架置入术后血清炎性标志物与缺血性脑血管事件的关系  

Association Between Serum Inflammatory Markers and Ischemic Cerebrovascular Events in Patients after Brain Artery Stenting

作　　者：刘芳[1] 刘加春[2] 王利军[2] 李金[1] 黄一宁[3] 王大明[2] 

机构地区：[1]卫生部北京医院神经内科,北京100730 [2]卫生部北京医院神经外科 [3]北京大学第一医院神经内科

出　　处：《血栓与止血学》2009年第3期118-121,共4页Chinese Journal of Thrombosis and Hemostasis

基　　金：卫生部临床学科重点项目(卫规财发[2001]321号)

摘　　要：目的探讨血清炎性标志物与脑动脉(颈动脉或椎-基底动脉)支架置入术后围手术期缺血性脑血管事件的关系。方法测定44例颈动脉或椎-基底动脉支架置入患者术后1 d的外周血中血清高敏C反应蛋白、基质金属蛋白酶-9及可溶性CD 40配体的水平,同时观察围手术期缺血性脑血管事件的发生情况。结果共有4例出现围手术期缺血性脑血管事件。血清基质金属蛋白酶-9在围手术期出现缺血性脑血管事件者中高于未出现者(1291.16±549.29 ng/ml vs 701.45±497.30 ng/ml,P=0.030),血清高敏C反应蛋白与可溶性CD 40配体在二者之间的差异无统计学意义。结论脑动脉支架置入术后的高基质金属蛋白酶-9水平可能与围手术期缺血性脑血管事件危险增加有一定的相关性。Objective To assess the association between levels of serum inflammatory markers and periproeedural isehemie eerebrovascular events（PICE） in patients undergoing brain artery （carotid or verte-brobasilar artery） stenting. Methods Serum high sensitivity C-reactive protein （hsCRP）, soluble CD 40 ligand （sCD 40L）and matrix metalloproteinase-9 （MMP-9）were assayed in peripheral blood samples obtained 1 d after stenting in 44 patients undergoing carotid or vertebrobasilar artery stenting, and the occurrence of PICE were observed as well. Results PICE presented in 4 cases. Levels of serum MMP-9 were higher in patients with PICE than in those without（ 1291.16 ±549.29 ng/ml vs 701.45 ±497.30 ng/ml,P =0. 030）. No differences were found for hsCRP and sCD 40L between patients with and without PICE. Conclusion High levels of serum MMP-9 ld after stenting may correlate with an increased risk of PICE in patients under-going brain artery stenting.

关 键 词：脑缺血 支架 C反应蛋白 CD 40配体 基质金属蛋白酶-9 

分 类 号：R743[医药卫生—神经病学与精神病学]