急性早幼粒细胞白血病患者网织血小板的检测与分析  

Peripheral Reticulated Platelet Levels in Patients with Acute Promyelocytic Leukemia and it's Clinical Significance

作　　者：孙明艳[1] 姜晓萍[1] 陈立君[1] 李家增[1] 马军[1] 

机构地区：[1]哈尔滨市第一医院哈尔滨血液病肿瘤研究所,哈尔滨150010

出　　处：《血栓与止血学》2009年第3期128-130,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的了解急性早幼粒细胞白血病(APL)患者外周血网织血小板(RP)水平的变化规律,为APL临床诊治过程中骨髓造血功能的恢复及掌握血小板输注时机与频率提供理论依据。方法采用流式细胞术测定27例APL患者及20名健康人RP%,并计数得出其相应的网织血小板绝对值(RPC)。结果初诊时(3.43±1.47)及治疗中(7.03±3.61)患者的RP%均较正常对照组(1.37±0.52)升高(P<0.05),而RPC(0.11±0.04,0.27±0.11)较正常对照组(0.35±0.10)明显降低(P<0.01);经化疗缓解时,其RP(3.87±1.08)及RPC(0.56±0.20)均高于正常对照组(P<0.05)。缓解期的RP%较初诊时无明显变化(P>0.05),RPC较初诊时明显增高(P<0.01)。结论在APL病程中连续检测RP及RPC的变化,有助于判断骨髓造血情况,同时为血小板输注与否的选择提供依据。Objective To investigate the changes of reticulated platelets （RP） levels in patients with acute promyelocytic leukemia（ APL）, and to provide some useful information about the recovery of hematogenesis for patients with APL during clinical treatment and whether platelets infusion is necessary. Methods The venous whole blood of 27cases APL patient and 20 normal controls RP expression were detected by flow cytometry. RPC was calculated according tO the formula count. Results RP in APL patients of incipient and treatment stage increased than that of control group （ P 〈 0.05 ）, but RPC of them low,red remarkably than that of control group （P 〈 0.01 ）. While complete remission（ CR）, RP and RPC were both higher than that of control group （ both P 〈 0.05 ）. The RP of relieved stage was closed to incipient stage （ P 〉 0.05 ）, but the RPC higher （P 〈 0.01 ）. Conclusion Continuously monitoring the RP and RPC could help hematologist to judge hematopoietic severity of APL status or chemotherapy induced bone marrow suppression cases and make decisions on whether patients need or not and what is the best time for platelet transfusion.

关 键 词：急性早幼粒细胞白血病 网织血小板(RP) 

分 类 号：R733.7[医药卫生—肿瘤]