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机构地区:[1]南昌大学研究生院医学部,2006级南昌330006 [2]南昌大学第一附属医院肿瘤科,南昌330006
出 处:《实用临床医学(江西)》2009年第3期14-15,17,共3页Practical Clinical Medicine
摘 要:目的探讨紫杉醇联合5-氟脲嘧啶(5-FU)、亚叶酸钙(CF)治疗晚期胃癌的疗效及不良反应。方法32例晚期胃癌患者均给予紫杉醇175 mg/m2加入5%葡萄糖注射液500 mL中3 h静脉滴注,第1天;CF 200 mg加入0.9%氯化钠注射液250 mL静脉滴注,第1-3天;5-FU 2 600 mg/m2用全自动电脑微量泵46 h泵入,第1-2天。3周重复。结果32例患者中,总有效率为43.8%,其中完全缓解(CR)4例,部分缓解(PR)10例,无变化(NC)14例,疾病进展(PD)4例。主要不良反应为:白细胞减少占75.0%,恶心、呕吐占71.9%,脱发占37.9%。结论紫杉醇联合5-FU、CF治疗晚期胃癌有较好的疗效,不良反应可以耐受。Objective To explore the curative effect and unhoward reactions of paelitaxel combined with 5-fluorouraeil(5-FU) and calcium folinate(CF) on advanced gastric cancer. Methods Thirty-two patients with advanced gastric cancer were all treated with paclitaxel 175 mg/m^2 in 500 mL 5% glucose injection for 3 hours on day 1 ,CF 200 mg in 250 mL sodium chloriae injection on day 1-3,5-FU 2 600 mg/m^2 fully-automatic continuous micropump for 46 hours by pump on day 1-2, repeated for three-weeks. Results Among 32 patients, the overall effective rate was 43.8% ,including 4 cases with complete remission(CR)and 10 cases with partial remission(PR), 14 cases without any change(NC) ,and 4 cases with disease progress(PD). The main untoward reactions were declined white blood cell (75. 0%), Nausea and vomiting (71. 9%), depilatory (37.9%). Conclusion The paclitaxel and 5-FU,CF had a comparative good curative effect on advanced gastric cancer and untoward reactions was tolerant.
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