A new method for preparing(2Z,4Z,6Z)-diethyl-4,5-oxepinedicarboxylates and some 1H-azepine analogues  

作　　者：Di Zao Li Zhong Fei Zheng Zhi Yun Kang De Quan Yu 

机构地区：[1]The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Peking Union Medical College,Ministry of Education,Institute of Materia Medico,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Chemical Letters》2009年第6期635-639,共5页中国化学快报(英文版)

基　　金：The National Natural Science Foundation of China(No.20372086) supported this work

摘　　要：A new method for preparing (2Z, 4Z, 6Z)-4,5-diethyloxepinedicarboxylate by one-step is described. The synthesis of several oxepines and azepines derivatives was carried out by the reaction of substituted furans or pyrroles with diethyl acetylenedicarboxylate in boiling toluene. The effect factors for this reaction were discussed and reaction condition was optimized.A new method for preparing (2Z, 4Z, 6Z)-4,5-diethyloxepinedicarboxylate by one-step is described. The synthesis of several oxepines and azepines derivatives was carried out by the reaction of substituted furans or pyrroles with diethyl acetylenedicarboxylate in boiling toluene. The effect factors for this reaction were discussed and reaction condition was optimized.

关 键 词：ACETYLENEDICARBOXYLATE FURANS PYRROLES CYCLOADDITION Oxepine AZEPINE 

分 类 号：O621.25[理学—有机化学]