supported by NSFC(22222111,21971198,and 22371215);National Key R&D Program of China(2022YFA1502902);Large-scale Instrument and Equipment Sharing Foundation of Wuhan University.Dr.Zhiwu Lu thanks China Postdoctoral Science Foundation(2022M712458)for the financial support.
Comprehensive Summary,The azepine ring is a prominent structural scaffold in biologically significant molecules. In this study, we present a Ni(II)-catalyzed asymmetric difunctionalization of alkynes, involving interm...
A facile and highly efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthene derivatives was achieved through cascade Knoevenagel-Michael condensations and cyclo-dehydration reaction utilizing tetrachlorosi...
Aim: To investigate whether multidrug resistance-associated protein 1 (MRP1) was responsible for drug resistence in refractory epi- lepsy in amygdale kindling rats. Methods: Rat amygdale kindling was used as a mod...
The National Natural Science Foundation of China(No.20372086) supported this work
A new method for preparing (2Z, 4Z, 6Z)-4,5-diethyloxepinedicarboxylate by one-step is described. The synthesis of several oxepines and azepines derivatives was carried out by the reaction of substituted furans or pyr...
carried out with the financial assistance of the National Natural Science Foundation of China (Project 20372015).
A convenient synthetic pathway to 2-aryl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[1,5-a]azepine derivatives 7 was developed.The synthesis was based on the cycloaddition of the 1,2,3,4-tetrahydronaphthalene α-acetoxy az...
Project supported partly by the National Natural Science Foundation of China (No. 20272002), the Excellent Young Teachers Program and the Sci-entific Research Foundation for the Returned Oversea Chinese Scholars of Ministry of Education of China, and
2a,4-Disubstituted 2,2a,3,4-tetrahydro-2-phenyl-1H-azeto[2,1-d][1,5]benzothiazepin-1-ones, as well as 2-substi- tuted 2,3-dihydro-3-phenylacetyl-2-styryl-benzothiazoles and 4a,6-disubstituted 3-benzyl-4a,5-dihydro-2-p...
Reaction of 1,5-benzothiazepine with N-protected glycine gives new a-amino-β-lactamderivatives of 1.5-benzothiazepine. The configuration and conformation of the products wereconfirmed by x-ray diffraction. The resu...
The crystal of the title compound C, C 30 H 30 N 2O 3S has been prepared by reaction of 1,5 benzothiazepine with N protected glycine and determined by X ray single crystal diffraction. Crystal data:...
1, 5-Benzothiazepines 1 react with phenylacetyl chloride to give the title compounds.The structures of these new compounds were confirmed by elemental analysis, ~1H NMR, ^(13)C NMRand MS spectroscopy, and their config...