AZEPINE

作品数:11被引量:19H指数:2
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相关领域:理学更多>>
相关作者:刘康更多>>
相关机构:武汉大学南开大学更多>>
相关期刊:《有机化学》《Chinese Journal of Structural Chemistry》《Acta Pharmacologica Sinica》《Chinese Journal of Chemistry》更多>>
相关基金:国家自然科学基金更多>>
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Ni-Catalyzed Enantioselective Difunctionalization of Alkynes to Azepine Derivatives Bearing a Quaternary Center and an Unprotected Imine
《Chinese Journal of Chemistry》2024年第8期873-878,共6页Jian Long Zhiwu Lu Xiao-Lin Li Peng Xue Wen-Bo Liu 
supported by NSFC(22222111,21971198,and 22371215);National Key R&D Program of China(2022YFA1502902);Large-scale Instrument and Equipment Sharing Foundation of Wuhan University.Dr.Zhiwu Lu thanks China Postdoctoral Science Foundation(2022M712458)for the financial support.
Comprehensive Summary,The azepine ring is a prominent structural scaffold in biologically significant molecules. In this study, we present a Ni(II)-catalyzed asymmetric difunctionalization of alkynes, involving interm...
关键词:Nickel Asymmetric catalysis N-HETEROCYCLES Alkyne functionalization Quaternary centers 
银催化γ-氨基酮与炔烃[5+2]环加成反应合成Azepine衍生物
《有机化学》2014年第1期230-230,共1页
环加成反应是有机合成中一类重要的反应,具有良好的原子经济性和高的合成效率,被广泛应用于合成各类环状化合物.尽管环加成反应目前已取得很大的进展,但仍然存在一些不足,尤其在合成七元及七元以上环状化合物方面,所报道的方法不...
关键词:环加成反应 反应合成 衍生物 银催化 环状化合物 炔烃 原子经济性 有机合成 
Silicon-mediated highly efficient synthesis of 1,8-dioxo-octahydroxanthenes and their transformation to novel functionalized pyrano-tetrazolo[1,5-a]azepine derivatives被引量:5
《Chinese Chemical Letters》2013年第5期404-406,共3页Hanan A.Soliman Tarek A.Salama 
A facile and highly efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthene derivatives was achieved through cascade Knoevenagel-Michael condensations and cyclo-dehydration reaction utilizing tetrachlorosi...
关键词:TETRACHLOROSILANE 1 8-Dioxo-octahydroxanthenes Synthesis Tetrazoln[1 5-a]azepines 
Multidrug resistance-associated protein I decreases the concentrations of antiepileptic drugs in cortical extracellular fluid in amygdale kindling rats被引量:9
《Acta Pharmacologica Sinica》2013年第4期473-479,共7页Ying-hui CHEN Cui-cui WANG Xia XIAO Li WEI Guoxiong XU 
Aim: To investigate whether multidrug resistance-associated protein 1 (MRP1) was responsible for drug resistence in refractory epi- lepsy in amygdale kindling rats. Methods: Rat amygdale kindling was used as a mod...
关键词:multidrug resistance-associated protein 1 refractory epilepsy amygdale kindling antiepileptic drug PHENYTOIN carbam-azepine cortex hippocampus MICRODIALYSIS 
A new method for preparing(2Z,4Z,6Z)-diethyl-4,5-oxepinedicarboxylates and some 1H-azepine analogues
《Chinese Chemical Letters》2009年第6期635-639,共5页Di Zao Li Zhong Fei Zheng Zhi Yun Kang De Quan Yu 
The National Natural Science Foundation of China(No.20372086) supported this work
A new method for preparing (2Z, 4Z, 6Z)-4,5-diethyloxepinedicarboxylate by one-step is described. The synthesis of several oxepines and azepines derivatives was carried out by the reaction of substituted furans or pyr...
关键词:ACETYLENEDICARBOXYLATE FURANS PYRROLES CYCLOADDITION Oxepine AZEPINE 
A convenient synthesis of 2-aryl substituted benzo[f][1,2,4]triazolo[1,5-a]azepine derivatives
《Chinese Chemical Letters》2007年第7期785-787,共3页Qing Qing Meng He Xiang Bai Feng Li Quan Rui Wang Feng Gang Tao 
carried out with the financial assistance of the National Natural Science Foundation of China (Project 20372015).
A convenient synthetic pathway to 2-aryl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[1,5-a]azepine derivatives 7 was developed.The synthesis was based on the cycloaddition of the 1,2,3,4-tetrahydronaphthalene α-acetoxy az...
关键词:Benzotriazoloazepine NITRILES 1 3-Dipolar cycloaddition Ring expansion 
Reaction of 2,3-Dihydro-1,5-benzothiazepines and Phenylacetyl Chloride in the Presence of Triethylamine:A New Aspect on the Formation Mechanism of Dihydro-1,3-oxazin-4-one Derivatives被引量:1
《Chinese Journal of Chemistry》2004年第9期1012-1018,共7页许家喜 王超 张奇涵 
Project supported partly by the National Natural Science Foundation of China (No. 20272002), the Excellent Young Teachers Program and the Sci-entific Research Foundation for the Returned Oversea Chinese Scholars of Ministry of Education of China, and
2a,4-Disubstituted 2,2a,3,4-tetrahydro-2-phenyl-1H-azeto[2,1-d][1,5]benzothiazepin-1-ones, as well as 2-substi- tuted 2,3-dihydro-3-phenylacetyl-2-styryl-benzothiazoles and 4a,6-disubstituted 3-benzyl-4a,5-dihydro-2-p...
关键词:1 5-benzothiazepine 2 2a 3 4-tetrahydro-1H-azeto[2 1-d][1 5]benzothiazepin-1-one 2 3-dihydro- benzothiazole 4a 5-dihydro-1H 6H-[1 3]oxazino[2 3-d][1 5]benzothiazepin-1-one cycloaddition mechanism 
Synthesis and Stereostructure of New β-Lactam Derivatives of1,5-Benzothiazepines
《Chinese Chemical Letters》1999年第6期447-448,共2页Yuan LI Na SUN Sheng JIN(Department of Chemistry Hebei University Shijiazhuang 050016 Institute of Chemistry and Molecular Engineering Peking University Beijing 100871) 
Reaction of 1,5-benzothiazepine with N-protected glycine gives new a-amino-β-lactamderivatives of 1.5-benzothiazepine. The configuration and conformation of the products wereconfirmed by x-ray diffraction. The resu...
关键词:1.5-Benzothiazepine Β-LACTAM stereospecific reaction 
Synthesis and Crystal Structure of α-( N-Protected a mino)β-lactam Derivative of 1 ,5-Benzothiazepine被引量:2
《Chinese Journal of Structural Chemistry》1999年第5期331-334,共4页李媛 金声  
The crystal of the title compound C, C 30 H 30 N 2O 3S has been prepared by reaction of 1,5 benzothiazepine with N protected glycine and determined by X ray single crystal diffraction. Crystal data:...
关键词:crystal structure  cycloaddition reaction    β lactam  1 5  benzothiazepine. 
Synthesis and Steric Structure of 1, 5-Benzothiazepine-Phenyl-β-Lactams
《Chinese Chemical Letters》1999年第1期23-26,共4页Yuan LI Jian Dong SHI Yuan Jing ZHANG  Sheng JIN Qi Yi XING(Department of Chemistry, Hebei Normal University. Shijiazhuang 050016 ShijiazhuangTeachers College 050041)(Beliing institute of Radiation Medicine, Beijing 100850)(Institute of Chemistry and 
1, 5-Benzothiazepines 1 react with phenylacetyl chloride to give the title compounds.The structures of these new compounds were confirmed by elemental analysis, ~1H NMR, ^(13)C NMRand MS spectroscopy, and their config...
关键词:1 5-BENZOTHIAZEPINE Β-LACTAM stereospecific reaction 
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