Β-LACTAM

作品数：32被引量：33H指数：3
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相关领域：理学医药卫生更多>>
相关作者：黄奕玮高昊更多>>
相关机构：中山医学大学国立中兴大学天津大学更多>>
相关期刊：《Global Health Journal》《Asian Pacific Journal of Tropical Medicine》《流程工业》《Science China Chemistry》更多>>
相关基金：国家自然科学基金北京市自然科学基金The Royal Society河北省自然科学基金更多>>
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Impact of Genetic Diversity of Uropathogenic Escherichia coli and Klebsiella pneumoniae Strains on the Dissemination of Extended Spectrum Beta-Lactam Resistance Genes in Côte d’Ivoire
《American Journal of Molecular Biology》2024年第4期230-244,共15页Innocent Allepo Abe Martial Kassi N’Djetchi Mélika Barkissa Traore Flora Yao Thomas Konan Konan Paulin Didier Sokouri Ibrahim Konate Mathurin Koffi 
The increase and spread of bacterial resistance to extended-spectrum beta-lactam antibiotics are reported in many infections and are a real public health problem worldwide. Drug pressure is a factor that favors the em...
关键词：Escherichia coli Klebsiella pneumoniae Extended-Spectrum β-Lactam Antibiotic Resistance Genetic Diversity 
Cinnamaldehyde targets SarA to enhance β-lactam antibiotic activity against methicillin-resistant Staphylococcus aureus
《mLife》2024年第2期291-306,共16页Jianguo Li Tingyin Lu Yuefei Chu Yuejun Zhang Jing Zhang Wenzhen Fu Jian Sun Yahong Liu Xiao-Ping Liao Yu-Feng Zhou 
supported by the Guangdong Basic and Applied Basic Research Foundation(2021A1515011079);the National Natural Science Foundation of China(32172909);the National Key Research and Development Program of China(2023YFD1800100 and 2022YFD1802100);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(32121004 and 32002337);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2019BT02N054);the Guangzhou Science and Technology Plan Project(2024A04J3412);the Double First-Class Discipline Promotion Project(2023B10564003).
Methicillin-resistant Staphylococcus aureus(MRSA)is a current global public health problem due to its increasing resistance to the most recent antibiotic therapies.One critical approach is to develop ways to revitaliz...
关键词：CINNAMALDEHYDE MRSA SARA β-lactamresistance 
Association ofβ-lactam antimicrobial's exposure with carbapenem-resistant Pseudomonas aeruginosa infection:a cumulative meta-analysis被引量：1
《Global Health Journal》2023年第3期137-146,共10页Prity Rani Deshwal Muskan Aggarwal Nalla Surender Reddy Raisa Fathima Pramil Tiwari 
Background:Carbapenems are effective against severe Pseudomonas aeruginosa nosocomial infections.Therefore,carbapenem-resistant Pseudomonas aeruginosa is a serious public health threat.An understanding of the risk of ...
关键词：CARBAPENEM-RESISTANT Pseudomonas aeruginosa Cumulative meta-analysis Β-LACTAMS 
Resistance of Klebsiella to Imipenem by Production of Carbapenemase Gene bla<sub>IMP</sub> at Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou, Burkina Faso
《International Journal of Clinical Medicine》2023年第8期347-356,共9页Blandine Ouédraogo Abdoul Karim Ouattara Amana Mètuor Dabiré Rahimatou Yasmine Wendkuni Tiemtoré Serge Sougé Jacques Simporé 
Objective: Class B carbapenemases are bacterial enzymes that catalyze the hydrolysis of β-lactam core antibiotics, except for monobactams. The objective of this study was to identify the carbapenemase gene blaIM...
关键词：KLEBSIELLA RESISTANCE blaIMPGenes Β-LACTAM Burkina Faso 
Exploitation of the antibacterial,antibiofilm and antioxidant activities of Salvadora Persica(Miswak)extract被引量：1
《Journal of Bioresources and Bioproducts》2023年第1期59-65,共7页Gamal M.El-Sherbiny Ahmed Mohamed Gazelly Mohammed H.Sharaf Saad A.Moghannemm Shehata M.E Mahmoud K.A.Ismail Ahmad S.El-Hawary 
The Salvadora persica(S.persica)L.chewing stick,usually known as miswak,is still being em-ployed as an oral hygiene agent for plaque and gingivitis prevention.This study aims to assess the antibacterial,antibiofilm,an...
关键词：β-lactam resistance Streptococcus species S.persica extract ANTIBACTERIAL ANTIBIOFILM ANTIOXIDANT GC-MS analysis 
Using tea nanoclusters asβ-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia:A promising therapeutic strategy by Chinese materioherbology被引量：3
《Fundamental Research》2022年第3期496-504,共9页Ziao Zhou Jun Li Lei Tan Xiangmei Liu Yufeng Zheng Zhenduo Cui Changyi Li Kelvin Wai Kwok Yeung Zhaoyang Li Yanqin Liang Shengli Zhu Shuilin Wu 
This work was jointly supported by the China National Funds for Distinguished Young Scientists(Grant No.51925104);National Natural Science Foundation of China(Grants No.51871162 and 52173251);RGC/NSFC(Grant No.N_HKU725-1616);Hong Kong ITC(Grants No.ITS/287/17,GHX/002/14SZ);Health and Medical Research Fund(Grant No.03142446).
β-lactamase,a kind of hydrolase in multi-drug resistant pathogens,can hydrolyzeβ-lactam antibiotics and make these kinds of antibiotics invalid.Small-molecular inhibitors about the enzyme and their mechanism are wid...
关键词：Materioherbology Antibacterial β-Lactam antibiotic PNEUMONIA Tea nanoclusters 
Synthesis, Crystal Structure and Antitumor Activities of 2-Acyl-β-lactam-2-carboxamides被引量：1
《Chinese Journal of Structural Chemistry》2019年第3期416-421,共6页GAO Hai-Tao WANG Hong-Mei HOU Na GUO Xing-Rong ZENG Xiao-Hua HU Yang-Gen 
Financial support from the National Natural Science Foundation of China(No.81773746);the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research,Hubei University of Medicine(No.WDCM009 and 2011JH-2014CXTT07);the Foundation of Health and Family planning Commission of Hubei Province(No.WJ2015Z113);the Foundation for Innovative Research Team of Hubei University of Medicine(2014CXZ01 and 2014CXZ05)
A series of 2-acyl-β-lactam-2-carboxamides was prepared through a tandem Ugi 4 CC/SN cyclization of bromoacetic acid, primary amine, arylglyoxal, and isocyanide. All of them were characterized by NMR, IR, MS and elem...
关键词：crystal structure 2-acyl-β-lactam-2-carboxamides SYNTHESIS CYTOTOXIC activity 
Open tubular capillary electrochromatography with block co-polymer coating for separation of β-lactam antibiotics
《Chinese Chemical Letters》2019年第2期349-352,共4页Liping Zhao Juan Qiao Hongyi Zhang Fangnan Xie Li Qi 
financial support from the National Natural Science Foundation of China (Nos. 21727809, 21635008, 21621062);Chinese Academy of Sciences(No. QYZDJ-SSW-SLH034)
A new open-tubular capillary electrochromatography (OT-CEC) method for analysis of β-lactam antibiotics has been developed with unique block co-polymer coating. To obtain the highly ordered block polymer chains, reve...
关键词：OPEN-TUBULAR capillary Electrochromatography Β-LACTAM antibiotics BLOCK CO-POLYMER COATING Serum drugs SEPARATION 
Ir-Catalyzed Asymmetric Hydrogenation of α-Alkylidene β-Lactams and Cyclobutanones被引量：3
《Chinese Journal of Chemistry》2018年第7期612-618,共7页Jingzhao Xia Yu Nie Guoqiang Yang Yangang Liu Ilya D. Gridnev Wanbin Zhang 
We thank the Shanghai Municipal Education Commission （No. 201701070002E00030）, the Science and Technology Commission of Shanghai Municipality （No. 15JC1402200）, and the National Natural Science Foundation of China （Nos. 21472123, 21572131, 21620102003） for financial support.
Chiral β-Iactams and cyclobutanones are present in numerous natural and pharmaceutical products. The stereoselective construction of chiral four-membered cyclic compounds is an ongoing challenge for the chemical comm...
关键词：Β-LACTAM CYCLOBUTANONE iridium phosphine-oxazoline ligand asymmetric hydrogenation 
Molecular Characterization and Correlation with β-lactam Resistance of Streptococcus pneumonia Isolates in Hangzhou,China被引量：7
《Biomedical and Environmental Sciences》2018年第5期389-393,共5页CHU Mei Fen LIU Xiao Xiang ZHANG Shao Ni HUANG Yan Ying2 3 DU Peng2 WANG Li Fang2 JI Lei2 YAN Jie4 5 SUN Ai Hua2 
supported by Grants from the National Natural Sciences Foundation of China[81772232];Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents
Penicillin-binding proteins（PBPs） are the target of β-lactam antibiotics（the major treatment for Streptococcus pneumoniae infections）,and mutations in PBPs are considered as a primary mechanism for the developmen...
关键词：PBP lactam Resistance of Streptococcus pneumonia Isolates in Hangzhou China RSP 
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