Β-LACTAMS

作品数：16被引量：47H指数：5
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相关领域：医药卫生化学工程更多>>
相关机构：海南省三亚市人民医院广西师范大学国立中兴大学北京化工大学更多>>
相关期刊：《北方药学》《Precision Chemistry》《数理医药学杂志》《Science China Chemistry》更多>>
相关基金：国家自然科学基金北京市自然科学基金中国博士后科学基金国家教育部博士点基金更多>>
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In vitro activity of β-lactamase inhibitors avibanvctam and relebactam in combination with β-lactams against multidrug-resistant Mycobacterium tuberculosis and mutations of resistance genes
《China Medical Abstracts(Internal Medicine)》2023年第4期222-222,共1页石洁 
Objective To evaluate the activity of six β-lactams in combination with three β-lactamase inhibitors against mycobacterium tuberculosis(MTB) in vitro.Methods A total of 105 multidrug-resistant tuberculosis (MDR-TB)s...
关键词：LACTAMASE MULTIDRUG TUBERCULOSIS 
Copper-Catalyzed Enantioconvergent Radical C(sp^(3))−N Cross- Coupling to Access Chiral α-Amino-β-lactams被引量：2
《Precision Chemistry》2023年第10期576-582,共7页Jing-Jing Zheng Wei-Long Liu Qiang-Shuai Gu Zhong-Liang Li Ji-Jun Chen Xin-Yuan Liu 
support from the National Key R&D Program of China(Nos.2021YFF0701604 and 2021YFF0701704);National Natural Science Foundation of China(Nos.22025103,92256301,21831002,and 22271133);Shenzhen Key Labor atory of Cross-Coupling Reactions(ZDSYS20220328104200001);Shenzhen Science and Technology Program(Nos.KQTD20210811090112004,JCYJ20200109141001789,JCYJ20220818100600001,and JCYJ202205300115409020).
A copper-catalyzed enantioconvergent radical C-(sp^(3))-N cross-coupling of racemic tertiaryα-bromo-β-lactams with aromatic amines is developed under mild thermal reaction conditions.The use of a sterically demanded...
关键词：copper asymmetric radical reactions CROSS-COUPLING aromatic amines chiralα-amino-β-lactams 
Association ofβ-lactam antimicrobial's exposure with carbapenem-resistant Pseudomonas aeruginosa infection:a cumulative meta-analysis被引量：1
《Global Health Journal》2023年第3期137-146,共10页Prity Rani Deshwal Muskan Aggarwal Nalla Surender Reddy Raisa Fathima Pramil Tiwari 
Background:Carbapenems are effective against severe Pseudomonas aeruginosa nosocomial infections.Therefore,carbapenem-resistant Pseudomonas aeruginosa is a serious public health threat.An understanding of the risk of ...
关键词：CARBAPENEM-RESISTANT Pseudomonas aeruginosa Cumulative meta-analysis Β-LACTAMS 
Synthesis of Chiral β-Lactams by Pd-Catalyzed Enantioselective Amidation of Methylene C(sp3)-H Bonds Enabled by a 2-Pyridylisopropyl Auxiliary
《Chinese Journal of Chemistry》2020年第5期527-528,共2页Ye-Qiang Han Tao Zhou 
In recent years,enantioselective C-H functionalization reactions have emerged as an efficient means to construct complicated chiral molecules.Compared to many precedents on the asymmetric functionalization of aryl C-H...
关键词：bonds breakthrough weakly 
Synthesis of Chiral β-Lactams by Pd-Catalyzed Enantioselective Amidation of Methylene C(sp3)-H Bonds被引量：7
《Chinese Journal of Chemistry》2020年第3期242-246,共5页Tao Zhou Meng-Xue Jiang Xu Yang Qiang Yue Ye-Qiang Han Yi Ding Bing-Feng Shi 
Financial support from the NSFC(Nos.21572201,21772170,21801223);the Chinese Postdoctoral Science Foundation(No.2017M621906);the Outstanding Young Talents of Zhejiang Prov-ince High-level Personnel of Special Support(ZJWR0108);the Fundamental Research Funds for the Central Universities(No.2018XZ2X001-02)is gratefully acknowledged.
A Pd(Ⅱ)-catalyzed enantioselective intramolecular amidation of both benzylic and unbiased methylene C(sp^3)-H bonds for the straightforward synthesis of chiral B-lactams from aliphatic carboxamides is reported.The co...
关键词：bonds straight CHIRAL 
Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillinresistant Staphylococcus aureus被引量：11
《Acta Pharmaceutica Sinica B》2019年第6期1174-1182,共9页Genzhu Wang Liang Li Xiukun Wang Xue Li Youwen Zhang Jie Yu Jiandong Jiang Xuefu You Yan Q.Xiong 
supported in part by CAMS Initiative for Innovative Medicine(grant numbers 2016-I2M-2-002 and 2016-I2M3-014,China);National Mega-project for Innovative Drugs(grant number 2018ZX09721001,China);the National Science Foundation of China(grant number 81621064,China).
Bacteremia is a life-threating syndrome often caused by methicillin-resistant Staphylococcus aureus(MRSA).Thus,there is an urgent need to develop novel approaches to successfully treat this infection.Staphylococcal ac...
关键词：Hyperiein Β-LACTAMS MRSA SYNERGISTIC effect SARA 
In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus被引量：8
《Acta Pharmaceutica Sinica B》2019年第3期496-504,共9页Qing Wang Yuemeng Lv Jing Pang Xue Li Xi Lu Xiukun Wang Xinxin Hu Tongying Nie Xinyi Yang Yan Q.Xiong Jiandong Jiang Congran Li Xuefu You 
supported by the National Natural Science Foundation of China (Grant Nos. 81621064 and 81361138020);CAMS Initiative for Innovative Medicine (Grant No. 2016-I2M-3-014, China);PUMC Youth Fund (Grant No. 3332013145, China);National Mega-project for Innovative Drugs (Grant No. 2018ZX09721001, China)
As D-amino acids play important roles in the physiological metabolism of bacteria,combination of D-amino acids with antibiotics may provide synergistic antibacterial activity. The aim of the study was to evaluate in v...
关键词：MRSA D-SERINE Β-LACTAMS COMBINATION SYNERGISTIC effect 
Ir-Catalyzed Asymmetric Hydrogenation of α-Alkylidene β-Lactams and Cyclobutanones被引量：3
《Chinese Journal of Chemistry》2018年第7期612-618,共7页Jingzhao Xia Yu Nie Guoqiang Yang Yangang Liu Ilya D. Gridnev Wanbin Zhang 
We thank the Shanghai Municipal Education Commission （No. 201701070002E00030）, the Science and Technology Commission of Shanghai Municipality （No. 15JC1402200）, and the National Natural Science Foundation of China （Nos. 21472123, 21572131, 21620102003） for financial support.
Chiral β-Iactams and cyclobutanones are present in numerous natural and pharmaceutical products. The stereoselective construction of chiral four-membered cyclic compounds is an ongoing challenge for the chemical comm...
关键词：Β-LACTAM CYCLOBUTANONE iridium phosphine-oxazoline ligand asymmetric hydrogenation 
Manganese-catalyzed bicyclic annulations of imines and α,β-unsaturated esters via C-H activation
《Science China Chemistry》2016年第10期1301-1305,共5页Yuanyuan Hu Congyang Wang 
supported by the National Basic Research Program of China (2012CB821600);the National Natural Science Foundation of China (21322203, 21272238, 21521002)
A manganese-catalyzed bicyclic annulation of imines with α,β-unsaturated esters via C–H activation is described, which provides an expedient access to fused β-lactams in one-step operation with high efficiency and...
关键词：Β-LACTAMS IMINES ALKENES MANGANESE C-H activation 
探讨肺炎克雷伯菌临床感染的护理方式及对β-lactams药物耐药性的主决定因素被引量：2
《北方药学》2013年第8期78-79,共2页黄妙娟 
目的:研究探讨肺炎克雷伯菌(本文以下使用英文简称"KNP")临床感染的护理方式及对药物耐药性的主决定因素。方法:2011年1月～2013年1月,于我院共选择110例患者作为研究对象。首先对患者实施积极的护理干预,以防止院内感染。之后对患者送...
关键词：肺炎克雷伯菌 临床感染 护理方式 Β-LACTAMS 耐药性 主决定因素 
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