Manganese-catalyzed bicyclic annulations of imines and α,β-unsaturated esters via C-H activation  

作　　者：Yuanyuan Hu Congyang Wang 

机构地区：[1]Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry,Chinese Academy of Sciences [2]University of Chinese Academy of Sciences

出　　处：《Science China Chemistry》2016年第10期1301-1305,共5页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China (2012CB821600);the National Natural Science Foundation of China (21322203, 21272238, 21521002)

摘　　要：A manganese-catalyzed bicyclic annulation of imines with α,β-unsaturated esters via C–H activation is described, which provides an expedient access to fused β-lactams in one-step operation with high efficiency and good functional group tolerance. Of note, both ketimines and aldimines are amenable to this transformation. Mechanistic studies have identified a five-membered azamanganacycle as the key reaction intermediate.A manganese-catalyzed bicyclic annulation of imines with α,β-unsaturated esters via C-H activation is described, which provides an expedient access to fused β-lactams in one-step operation with high efficiency and good functional group tolerance. Of note, both ketimines and aldimines are amenable to this transformation. Mechanistic studies have identified a five-membered azamanganacycle as the key reaction intermediate.

关 键 词：Β-LACTAMS IMINES ALKENES MANGANESE C-H activation 

分 类 号：O621.251[理学—有机化学]