云南高校图书馆联盟文献共享服务平台- D-SERINE

D-SERINE: 作品数：14被引量：30H指数：2; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：马铁刘永红陈良为崔琰吴继红更多>>; 相关机构：第四军医大学西京医院第四军医大学空军军医大学（第四军医大学）广东药科大学更多>>; 相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Neural Regeneration Research》《中国药理学通报》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金广州市科技计划项目更多>>

DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis: 《Science China(Life Sciences)》2025年第2期467-483,共17页Xiao Liu Chaojuan Yang Zhuoran Lin Jianing Li Bin Yin Xuepei Lei Wei Han Boqin Qiang Pengcheng Shu Chen Zhang Xiaozhong Peng; supported by the National Science and Technology Innovation 2030 Grants of China(2021ZD0200902 to Peng,X.);the National Key Research and Development Program of China(2017YFA0105201 to Zhang,C.);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS;2021-1-I2M-019 to Shu,P.and 2021-1-I2M-024 to Peng,X.);the National Natural Science Foundation of China(31670789 to Peng,X.,32370883 to Shu,P.,81925011 to Zhang,C.,82001145 to Yang,C.);the State Key Laboratory Special Fund 2060204。; D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological processes.Daminoacyl-t RNA deacylase 1(DTD1)may biochemically contribute to D-serine or D-aspartate ...; 关键词：D-aminoacyl-tRNA deacylase 1 D-SERINE D-ASPARTATE synaptic transmission neuronal morphology spatial learning and memory

Corticosterone induced D-serine release deficit play an important role in long-term potentiation impairment by corticosterone in perforant path-dentate gyrus pathway: 《中国药理学与毒理学杂志》2021年第10期764-764,共1页HUANG Yan WANG Chen YU Qi LI Dong SUN Na ZHANG Yong-xiang ZHOU Wen-xia; OBJECTIVE Previous studies showed that over activation of NMDA receptors may be a crucial cause of long-term potentiation(LTP)and cognitive impairment induced by stress or corticosterone.However,other studies showed t...; 关键词：CORTICOSTERONE long-term potentiation N-methyl-D-aspartate receptors D-SERINE Na+-independent ala⁃nine-serine-cysteine transporter-1

Parvalbumin interneurons in anterior cingu⁃late cortex regulate cognitive behaviors in methylazoxymethanol acetate model of schizophrenia: 《中国药理学与毒理学杂志》2021年第9期666-667,共2页ZHANG Xiao-qin XU Le YU Zhi-peng SHEN Hao-wei; OBJECTIVE Cognitive dysfunc⁃tion is a core disturbance of schizophrenia,appear to emerge from impaired neural activity.The anterior cingulate cortex(ACC)is an integra⁃tion hub for higher-order thalamic inputs impor⁃ta...; 关键词：methylazoxymethanol acetate cognitive function PARVALBUMIN INTERNEURONS D-SERINE

D-serine reduces memory impairment and neuronal damage induced by chronic lead exposure被引量：2: 《Neural Regeneration Research》2021年第5期836-841,共6页Jian-Zhu Bo Ling Xue Shuang Li Jing-Wen Yin Zheng-Yao Li Xi Wang Jun-Feng Wang Yan-Shu Zhang; This study was supported by the National Natural Science Foundation of China,Nos.81673208(to YSZ),and 31802194(to SL).; Although exogenous D-serine has been applied as a neural regulatory intervention in many studies,the role played by D-serine in hippocampal injuries caused by lead exposure remains poorly understood.Rat models of chro...; 关键词：D-SERINE HIPPOCAMPUS LEAD neurological function N-METHYL-D-ASPARTATE POISONING protection REPAIR

D-serine对阿尔茨海默病模型小鼠海马区tau蛋白过度磷酸化的影响被引量：2: 《神经解剖学杂志》2019年第4期418-424,共7页刘鸿庆贾会涂幸古梓婷田素民刘靖李国营马宇昕; 广州市科技计划项目科技创新人才专项-珠江科技新星(201710010002);广东省自然科学基金(2018A0303130073); 目的:探讨D-丝氨酸(D-serine)对阿尔茨海默病(AD)模型小鼠海马区tau蛋白过度磷酸化的影响。方法:42只SPF级昆明小鼠随机分为6组:Control组、Saline组、Aβ组、Aβ+D-serine组、Aβ+DAAO组、Aβ+BE组;每组7只动物。AD模型组小鼠双侧海马...; 关键词：淀粉样蛋白 D-SERINE TAU蛋白海马过度磷酸化小鼠

In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus被引量：8: 《Acta Pharmaceutica Sinica B》2019年第3期496-504,共9页Qing Wang Yuemeng Lv Jing Pang Xue Li Xi Lu Xiukun Wang Xinxin Hu Tongying Nie Xinyi Yang Yan Q.Xiong Jiandong Jiang Congran Li Xuefu You; supported by the National Natural Science Foundation of China (Grant Nos. 81621064 and 81361138020);CAMS Initiative for Innovative Medicine (Grant No. 2016-I2M-3-014, China);PUMC Youth Fund (Grant No. 3332013145, China);National Mega-project for Innovative Drugs (Grant No. 2018ZX09721001, China); As D-amino acids play important roles in the physiological metabolism of bacteria,combination of D-amino acids with antibiotics may provide synergistic antibacterial activity. The aim of the study was to evaluate in v...; 关键词：MRSA D-SERINE Β-LACTAMS COMBINATION SYNERGISTIC effect

S1A-5 Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects Against Amyloid-Beta-Induced Neurotoxicity: 《神经药理学报》2018年第4期25-26,共2页ZHOU Wen-xia HUANG Yan SHEN Wei SU Jie CHENG Bin LI Dong LIU Gang ZHANG Yong-xiang; The unbalance between synaptic(GluN2A,mediating the protective pathway)and extrasynaptic NMDA receptors(NMDARs)(GluN2B,mediating the excitotoxic pathway)has been found in Alzheimer’s disease(AD),indicating restoring ...; 关键词：GluN2B-selective ANTAGONIST NMDRs similar to D-SERINE

D-serine合成相关丝氨酸消旋酶在大鼠和癫痫患者海马的分布与细胞定位被引量：1: 《神经解剖学杂志》2015年第6期723-728,共6页马铁张颖史亮白洁陈良为刘永红; 国家自然科学基金(31371374;31401176); 目的:观察D-serine合成相关的丝氨酸消旋酶(SR)在大鼠和癫痫病人海马组织的分布与细胞定位特点。方法:成年和幼龄SD大鼠灌流固定、冰冻切片癫痫患者海马硬化石蜡切片,进行SR、SR/NeuN、SR/GFAP免疫荧光染色、激光共聚焦显微镜观察和计...; 关键词：丝氨酸消旋酶右旋丝氨酸癫痫海马大鼠

Activity-dependent sulfhydration of serine racemase controls synaptic plasticity in the hippocampus via increasing D-serine availability: 《中国药理学通报》2015年第B11期51-51,共1页; Aims More and more advances show that hydrogen sulfide （H2S） sulfhydrates functional proteins and regulates their actions. However, much less is known about the endogenous sulfhydration of key proteins under physiol...; 关键词：hydrogen sulfide (H2S) POLYSULFIDES sulfhydration D-SERINE SERINE RACEMASE (SR) synapticplasticity

Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats:Implications for affective pain被引量：15: 《Neuroscience Bulletin》2012年第1期77-87,共11页Hong Cao Wen-Hua Ren Mu-Ye Zhu Zhi-Qi Zhao Yu-Qiu Zhang; supported by the National Natural Science Foundation of China (30900444,31070973,30870835,31121061 and 30830044); Objective The rostral anterior cingulate cortex （rACC） is implicated in processing the emotional component of pain. N-methyl-D-aspartate receptors （NMDARs） are highly expressed in the rACC and mediate painrelated ...; 关键词：N-methyl-D-aspartate receptor glycine site GIuN2B D-SERINE extracellular regulated kinase/cAMP-response element-binding protein signaling pathway rostral anterior cingulate cortex

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