D-ASPARTATE

作品数：16被引量：27H指数：3
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DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis
《Science China(Life Sciences)》2025年第2期467-483,共17页Xiao Liu Chaojuan Yang Zhuoran Lin Jianing Li Bin Yin Xuepei Lei Wei Han Boqin Qiang Pengcheng Shu Chen Zhang Xiaozhong Peng 
supported by the National Science and Technology Innovation 2030 Grants of China(2021ZD0200902 to Peng,X.);the National Key Research and Development Program of China(2017YFA0105201 to Zhang,C.);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS;2021-1-I2M-019 to Shu,P.and 2021-1-I2M-024 to Peng,X.);the National Natural Science Foundation of China(31670789 to Peng,X.,32370883 to Shu,P.,81925011 to Zhang,C.,82001145 to Yang,C.);the State Key Laboratory Special Fund 2060204。
D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological processes.Daminoacyl-t RNA deacylase 1(DTD1)may biochemically contribute to D-serine or D-aspartate ...
关键词：D-aminoacyl-tRNA deacylase 1 D-SERINE D-ASPARTATE synaptic transmission neuronal morphology spatial learning and memory 
Chinese Tuina remodels the synaptic structure in neuropathic pain rats by downregulating the expression of N-methyl D-aspartate receptor subtype 2B and postsynaptic density protein-95 in the spinal cord dorsal horn被引量：5
《Journal of Traditional Chinese Medicine》2023年第4期715-724,共10页HUANG Hongye WANG Bingqian CHEN Shuijin FANG Jiayu WANG Xiaohua CHEN Lechun JIANG Yu ZHANG Huanzhen CHEN Jincheng LIN Zhigang 
Natural Science Foundation-funded Project:Study on the Mechanism of Tuina and Tuina in Regulating the Synaptic Plasticity of Spinal Dorsal Horn in Lumbar Disc Herniation Based on LncRNA-HOTAIR/miR-219 Mediated NMDAR Pathway(No.82174523);Natural Science Foundation of Fujian Province:Study on the Mechanism of Tuina Regulating the Synaptic Plasticity of Spinal Dorsal Horn in Lumbar Disc Herniation based on NMDAR-CAMK2-CREB Pathway(No.2020J01757);Study on Analgesic Mechanism of Tuina on Neuropathic Pain in Spinal Dorsal Horn/ACC Brain Region based on PKA-NMDA-NR2B Pathway(No.2020J01758);Fujian Health Science and Technology Program:Study on the Analgesic Mechanism of Tuina Manipulation On Lumbar Disc Herniation from the Efficacy of miR-219/NR2B Mediated Synaptic Transmission(No.2020GGA070);Effects of Tuina Point Press on AMPA/NMDA Receptor Scaffold Protein and Synaptic Plasticity in Spinal Dorsal Horn of Rats with Neuropathic Pain(No.2020CXA052)。
OBJECTIVE:To investigate whether the Chinese massage system,Tuina,exerts analgesic effects in a rat model of chronic constriction injury(CCI)by remodeling the synaptic structure in the spinal cord dorsal horn(SCDH).ME...
关键词：NEURALGIA spinal cord dorsal horn receptors N-METHYL-D-ASPARTATE disks large homolog 4 protein neuronal plasticity Chinese Tuina 
Role of D-aspartate on biosynthesis,racemization,and potential functions:A mini-review被引量：3
《Animal Nutrition》2018年第3期311-315,共5页Yuying Li Hui Han Jie Yin Tiejun Li Yulong Yin 
supported by Hunan Province key research and development projects(2017NK2321);National Basic Research Program of China(973)(2013CB127301);National Natural Science Foundation of China(31472106);China Agriculture Research System(CARS-35)
D-aspartate, a natural and endogenous amino acid, widely exists in animal tissues and can be synthesized through aspartate racemase and transformed by D-aspartate oxidase(DDO). D-aspartate mainly serves as a neurotran...
关键词：D-ASPARTATE BIOSYNTHESIS RACEMIZATION NUTRITION FUNCTIONS 
Neuroprotective effect of deferoxamine on N-methyI-D-aspartate-induced excitotoxicity in RGC-5 cells被引量：1
《Acta Biochimica et Biophysica Sinica》2017年第9期827-834,共8页Ying Tian Ye He Weitao Song Endong Zhang Xiaobo Xia 
This study was supported by a grant from the National Natural Science Foundation of China （No. 81670858）.
Many N-methyl-o-aspartate （NMDA） receptor antagonists have been used to treat neurodegenera- tive diseases induced by glutamate excitotoxicity in clinics. However, the universality of the glutamic acid neurotransmit...
关键词：N-methyl-o-aspartate EXCITOTOXICITY DEFEROXAMINE NEUROPROTECTION 
Regulation of acupuncture on NMDAR1 mRNA expression in visual cortex of monocularly-deprived rats被引量：11
《Journal of Acupuncture and Tuina Science》2017年第1期1-7,共7页Zhu Tian-tian Chen Cheng Yan Xing-ke 
supported by National Natural Science Foundation of China,No.81260560~~
Objective： To explore the molecular biological mechanism of acupuncture in intervening visual deprivation. Methods： Forty-eight 2-week old Wistar rats were randomly divided into a normal group, a model group, and 6 ...
关键词：Acupuncture Therapy AMBLYOPIA Receptors  N-MethyI-D-Aspartate NMDA receptor A1 Evoked Potentials  Visual RATS 
Potential Effect of Preoperative Immunotherapy on Anesthesia of Patients with Anti-N-methyI-D-aspartate Receptor Encephalitis
《Chinese Medical Journal》2015年第21期2972-2975,共4页Ya-Hong Gong Ming-Zhu Zhang Xiu-Hua Zhang Hong-Zhi Guan Xie-Qun Xu Yu-Guang Huang 
Anti-N-methyl-D-aspartate receptor （anti-NMDA-R） encephalitis is a newly recognized neuro-autoimmune disease. Patients usually present with a series of neurological and psychiatric syndromes including memory impairm...
关键词：ANESTHESIA Anti-N-methyl-D-aspartate Receptor Encephalitis IMMUNOTHERAPY 
Neuroprotective effects of Asiaticoside被引量：3
《Neural Regeneration Research》2014年第13期1275-1282,共8页Feng-yan Qi Le Yang Zhen Tian Ming-gao Zhao Shui-bing Liu Jia-ze An 
supported by the National Natural Science Foundation of China,No.31271126,81372606
In the central nervous system, Asiaticoside has been shown to attenuate in vitro neuronal damage caused by exposure to β-amyloid. In vivo studies demonstrated that Asiaticoside could attenuate neurobehavioral, neuroc...
关键词：nerve regeneration brain injury ASIATICOSIDE apoptosis N-methfl-D-aspartate GLUTAMATE NEUROTRANSMITTER NEUROTOXICITY calcium imaging B^t-2 Bax NSFC grant neural regeneration 
Zinc reverses glycine-dependent inactivation of NMDARs in cultured rat hippocampal neurons
《Science China(Life Sciences)》2012年第12期1075-1081,共7页LI Xia CHEN ZhaoQin JIANG Zheng LI YeFei ZHANG YunFeng 
supported by the National Basic Research Program of China (Grant No. J20110170);the National Natural Science Foundation of China (Grant Nos. 81000497 and 81071614)
In the presence of glutamate and co-agonists, e.g., glycine, the N-methyl-D-aspartate receptor （NMDAR） plays an important role in physiological and pathophysiological brain processes. Previous studies indicate glyci...
关键词：N-methyI-D-aspartate （NMDA） NMDARs （NMDARs） GLYCINE ZINC INACTIVATION hippocampal neurons 
D-Aspartate, a Key Element for the Improvement of Sperm Quality
《Advances in Sexual Medicine》2012年第4期45-53,共9页Gemma D’Aniello Salvatore Ronsini Tiziana Notari Natascia Grieco Vincenzo Infante Nicola D’Angel Fara Mascia Maria Maddalena Di Fiore George Fisher Antimo D’Aniello 
Introduction: D-Aspartate is an endogenous amino acid involved in LH and testosterone release in humans. In this study we investigate the impact of nutritional supplementation of sodium D-aspartate on the improvement ...
关键词：D-ASPARTATE Oligo-Asthenozoospermia ASTHENOZOOSPERMIA PREGNANCIES 
A non-opioid pathway for dynorphin-caused spinal cord injury in rats被引量：1
《Neural Regeneration Research》2012年第11期815-820,共6页Yu Chen Liangbi Xiang Jun Liu Dapeng Zhou Hailong Yu Qi Wang Wenfeng Han Mingming Guo 
supported by the Science and Key Technology Research and Development Program of Liaoning Province, No. 2011225021, 2011225041
Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory am...
关键词：spinal cord injury DYNORPHIN kappa opioid receptor antagonist N-methyI-D-aspartate receptor antagonist motor function acid phosphatase 
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