ASTHENOZOOSPERMIA

作品数：24被引量：44H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：张哲杨宇卓王利更多>>
相关机构：湖北中医药大学北京大学北京大学第三医院更多>>
相关期刊：《Reproductive and Developmental Medicine》《中国科学技术大学学报》《Chinese Medical Journal》《Advances in Sexual Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Novel mutations in LRRC23 cause asthenozoospermia in a nonconsanguineous family
《Asian Journal of Andrology》2024年第5期484-489,共6页Song-Xi Tang Si-Yu Liu Hong Xiao Xin Zhang Zhuang Xiao Shan Zhou Yi-Lang Ding Peng Yang Qiang Chen Hai-Lin Huang Xi Chen Xi Lin Hui-Liang Zhou Ming-Xi Liu 
supported by the National Key Research and Development Program of China(No.2022YFC2702702);National Natural Science Foundation of China(No.32270899 and No.32070842);the Natural Science Foundation of Jiangsu Province(No.BK20230004);Young and Middle-Aged Key Personnel Training Project of the Fujian Provincial Health Commission(2019-ZQN-62);Fujian Provincial Finance Project(BPB-TSX2021).
The cause of asthenozoospermia(AZS)is not well understood because of its complexity and heterogeneity.Although some gene mutations have been identified as contributing factors,they are only responsible for a small num...
关键词：ASTHENOZOOSPERMIA LRRC23 male infertility whole exome sequencing 
Scriptaid is a prospective agent for improving human asthenozoospermic sample quality and fertilization rate in vitro
《Asian Journal of Andrology》2024年第5期490-499,共10页Yi-Ting Yang Bin Yan Li-Na Guo Miao Liu Yu-Hua Li Zhi-Yu Shao Hua Diao Su-Ying Liu He-Guo Yu 
Male infertility is a global issue caused by poor sperm quality,particularly motility.Enhancement of the sperm quality may improve the fertilization rate in assisted reproductive technology(ART)treatment.Scriptaid,wit...
关键词：ASTHENOZOOSPERMIA HDAC6 ICSI Scriptaid sperm motility 
A novel missense mutation in QRICH2 causes male infertility due to multiple morphological abnormalities of the sperm flagella
《中国科学技术大学学报》2024年第9期24-32,68,69,共11页Yousaf Raza Huan Zhang Muhammad Zubair Ansar Hussain Nisar Ahmad Min Chen Gang Yang Musavir Abbas Tanveer Abbas Muhammad Shoaib Ghulam Mustafa Imtiaz Ali Meftah Uddin Suixing Fan Wasim Shah Qinghua Shi 
supported by the National Key Research and Development Program of China(2021YFC2700202,2022YFA0806303 and 2022YFC2702601);the Global Select Project of the Institute of Health and Medicine,Hefei Comprehensive National Science Center(DJK-LX-2022010);USTC Research Funds of the Double First-Class Initiative(the Joint Fund for New Medicine of USTC)(YD9100002034);the Fundamental Research Funds for the Central Universities(WK9100000004).
Multiple morphological abnormalities of the sperm flagella(MMAF)are characterized by bent,irregular,short,coiled,and absent flagella.MMAF is caused by a variety of genes,some of which have been identified.However,the ...
关键词：male infertility MMAF ASTHENOZOOSPERMIA QRICH2 missense mutation 
A novel homozygous splice variant in DNAAF4 is associated with asthenozoospermia
《Acta Biochimica et Biophysica Sinica》2023年第10期1689-1692,共4页Xiaobin Zhu Chen Chen Jian Song Shijue Dong Xuhui Zeng Zhihong Niu Yanwei Sha Xiaoning Zhang 
supported by the grants from the Nantong Social and People’s Livelihood Science and Technology Plan(No.MS22022087 to X.Z.);the Basic Science Research Program of Nantong(No.JC22022086 to X.Z.).
Primary ciliary dyskinesia(PCD)is an autosomal recessive disorder with a high degree of genetic and phenotypic heterogeneity resulted from defects in the structural characteristics and motility of flagella and cilia[1...
关键词：PRIMARY MOTILITY HARBOR 
Association between semen collection time and semen parameters:an observational study
《Asian Journal of Andrology》2023年第3期339-344,共6页Shun Bai Xian-Chao Dou Hao-Lin Qi Yan-Song Zhu Yin-Tao Zhang Yi-Xun Liu Xue-Chun Hu Cheng Cao Xian-Hong Tong Bo Xu Li-Min Wu Xiao-Hua Jiang 
This study was supported by the National Natural Science Foundation of China(81901543,81971446,81971333 and 82071709);the National Key R&D Program of China(2018YFC1003900);the National Key Research and Development Project(2019YFA0802600).
The process of semen collection plays a key role in the quality of semen specimens.However,the association between semen collection time and semen quality is still unclear.In this study,ejaculates by masturbation from...
关键词：ASTHENOZOOSPERMIA semen collection time semen quality TERATOZOOSPERMIA 
Polymorphism of mitochondrial DNA genes involved in asthenozoospermia in infertile patients of Côte d'Ivoire
《Reproductive and Developmental Medicine》2023年第1期38-43,共6页Jules Erick Hermann Ayekoue Konan Guy Sylvère N’zi Ako Aristide Berenger Ako Marie-Florence N’guessan Yapi Guillaume Yayé FounzéguéAmadou Coulibaly Allico Joseph Djaman 
Objective:The relationship between mitochondrial DNA(mtDNA)polymorphisms and abnormalities in sperm quality has been the subject of several studies,with the objective of improving the treatment of male infertility.Thi...
关键词：ASTHENOZOOSPERMIA Côte d'Ivoire Institute of Pasteur Côte d'Ivoire male infertility mtDNA polymorphism 
Semen microbiota in normal and leukocytospermic males被引量：1
《Asian Journal of Andrology》2022年第4期398-405,共8页Ye Yao Xin-Jian Qiu Dong-Sheng Wang Jie-Kun Luo Tao Tang Yun-Hui Li Chun-Hu Zhang Hao Liu Lu Zhou Lin-Lin Zhao 
supported by Youth Foundation of National Natural Science Foundation of China(No.81703963 and No.81202807);the Natural Science Foundation of Hunan(No.2018JJ2667 and No.2019JJ40511);the Scientific Research Project of Chinese Traditional Medicine Administration Bureau in Hunan Province(No.201806).
Large numbers of microbes can be present in seminal fluid,and there are differences in the semen microbiota between normal and abnormal semen samples.To evaluate the semen microbiota in patients with leukocytospermia,...
关键词：16S rRNA gene sequencing ASTHENOZOOSPERMIA LEUKOCYTOSPERMIA semen microbiota sperm motility 
Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure被引量：2
《Acta Biochimica et Biophysica Sinica》2021年第10期1300-1309,共10页Xiaoli Wei Yanwei Sha Zijie Wei Xingshen Zhu Fengming He Xiaoya Zhang Wensheng Liu Yifeng Wang Zhongxian Lu 
This work was supported by the grants from the National Natu-ral Science Foundation of China(Nos.82071697 and 82001616);the Medical and Health Guidance Project of Xiamen(No.3502Z20199140).
Asthenozoospermia is the most common cause of male infertility.Dynein protein arms play a crucial role in the motility of both the cilia and flagella,and defects in these proteins generally impair the axoneme structur...
关键词：ASTHENOZOOSPERMIA whole-exome sequencing DNAH7 bi-allelic mutation 
Gene transcription profiting of astheno-and normo-zoospermic sperm subpopulations被引量：2
《Asian Journal of Andrology》2020年第6期608-615,共8页Pedro Caballero-Campo Saul Lira-Albarran David Barrera Elizabeth Borja-Cacho Hector S Godoy-Morales Claudia Rangel-Escareno Fernando Larrea Mayel Chirinos 
Spermatozoa contain a repertoire of RNAs considered to be potential functional fertility biomarkers.In this study,the gene expression of human sperm subpopulations with high(F1)and low(F2)motility from healthy normozo...
关键词：ASTHENOZOOSPERMIA male in fertility MICROARRAY SPERM TRANSCRIPTOME 
The expression of the new epididymal luminal protein of PDZ domain containing 1 is decreased in asthenozoospermia
《Asian Journal of Andrology》2018年第2期154-159,共6页A-Juan Liang Gui-Shuan Wang Ping Ping Shuang-Gang Hu Yu Lin Yi Ma Zheng-Zheng Duan Han-Shu Wang Fei Sun 
This work was supported by the National Natural Science Foundation of China Grants （81430027 and 81671510 to FS; 81501309 to GSW） and the National Basic Research Program of China （2014CB943100 to FS）.
Spermatozoa are not mature until they transit the epididymis where they acquire motility and the ability to fertilize an egg through sequential modifications. The epididymis has three functional regions, caput, corpus...
关键词：ASTHENOZOOSPERMIA EPIDIDYMIS FERTILITY PDZ domain containing 1 SPERM 
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