Objective:To determine the relationship between teratozoospermia and sperm DNA fragmentation(SDF)in the human ejaculate.Methods:This retrospective study included 100 normozoospermic men as a control cohort(abnormal fo...
This study was supported by the National Natural Science Foundation of China(No.32200485);the University Synergy Innovation Program of Anhui Province(GXXT-2021-071);Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01).
Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to date.While several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,th...
Teratozoospermia is an infertility issue that affects a significant number of couples of reproductive age. One of the potential causes contributing to the global decline in seminal quality includes factors such as die...
This work was funded by the grant from the National Natural Science Foundation of China(No.32170862).
Dear Editor,An interesting article from Zhao et al.recently published in Asian Journal of Andrology,has shown the association of a novel loss-of function(LOF)variant in PARN-like ribonuclease domain-containing exonucl...
supported by grants from the National Key Research and Development Program of China(2022YFC2702604);the National Natural Science Foundation of China(82171608,82201773,and 81971447);the China Postdoctoral Science Foundation(2022M711119);the Scientific Research Foundation of the Health Committee of Hunan Province(B202301039323 and B202301039518).
Male infertility is a major reproductive disorder,which is clinically characterized by highly heterogeneous phenotypes of abnormal sperm count or quality.To date,five male patients with biallelic loss-of-function(LOF)...
This research was supported by the National Key Research and Development Project(No.2019YFA0802600);the National Natural Science Foundation of China(No.82101685,No.82171599,and No.81971333);2020 Basic and Clinical Cooperative Research Promotion Program of Anhui Medical University(No.2020xkjT014).
Teratozoospermia is a rare disease associated with male infertility.Several recurrent genetic mutations have been reported to be associated with abnormal sperm morphology,but the genetic basis of tapered-head sperm is...
This study was supported by the National Natural Science Foundation of China(81901543,81971446,81971333 and 82071709);the National Key R&D Program of China(2018YFC1003900);the National Key Research and Development Project(2019YFA0802600).
The process of semen collection plays a key role in the quality of semen specimens.However,the association between semen collection time and semen quality is still unclear.In this study,ejaculates by masturbation from...
supported by the National Natural Science Foundation of China(31930063,81771533,81901531,31971137,and 81871163);the National Key Research and Development Program of China(2018YFC2000102,2018YFA0107004,and 2018YFC1003000);the Shanghai Municipal Health Commission and Collaborative Innovation Cluster Project(2019CXJQ01);SHIPM-pi Fund(JY201801);SHIPM-mu Fund(JC201802)。
Teratozoospermia is usually associated with defective spermiogenesis and is a disorder with considerable genetic heterogeneity. Although previous studies have identified several teratozoospermia-associated genes, the ...
supported by Shanghai Municipal Science and Technology Major Project(No.:2017SHZDZX01).
The head of sperm was imaged with domestic digital holographic microscopy(DHM),and then the quantitative three-dimensional size information of normal sperm and teratozoospermic sperm was compared and analyzed.DHM sper...
BACKGROUND Epigenetic disruptions have been implicated in some cases of infertility and can serve as therapeutic targets.However,the involvement of epigenetics in infertility has not received adequate attention.AIM Th...