Association between semen collection time and semen parameters:an observational study  

作　　者：Shun Bai Xian-Chao Dou Hao-Lin Qi Yan-Song Zhu Yin-Tao Zhang Yi-Xun Liu Xue-Chun Hu Cheng Cao Xian-Hong Tong Bo Xu Li-Min Wu Xiao-Hua Jiang 

机构地区：[1]Reproductive and Genetic Hospital,The First Affiliated Hospital of University of Science and Technology of China,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China [2]School of Medical Imaging,Bengbu Medical University,Bengbu 233030,China [3]The First Clinical Medical School,Anhui Medical University,Hefei 230022,China [4]School of Life Science,Anhui Medical University,Hefei 230022,China [5]Department of Biochemistry and Molecular Biology,Anhui Medical University,Hefei 230022,China [6]Department of Urology,The First Affiliated Hospital of University of Science and Technology of China,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China

出　　处：《Asian Journal of Andrology》2023年第3期339-344,共6页亚洲男性学杂志（英文版）

基　　金：This study was supported by the National Natural Science Foundation of China(81901543,81971446,81971333 and 82071709);the National Key R&D Program of China(2018YFC1003900);the National Key Research and Development Project(2019YFA0802600).

摘　　要：The process of semen collection plays a key role in the quality of semen specimens.However,the association between semen collection time and semen quality is still unclear.In this study,ejaculates by masturbation from 746 subfertile men or healthy men who underwent semen analysis were examined.The median(interquartile range)semen collection time for all participants was 7.0(5.0-11.0)min,and the median time taken for semen collection was lower in healthy men than that in subfertile men(6.0 min vs 7.0 min).An increase in the time required to produce semen samples was associated with poorer semen quality.Among those undergoing assisted reproductive technology(ART),the miscarriage rate was positively correlated with the semen collection time.After adjusting for confounders,the highest quartile(Q4)of collection time was negatively associated with semen volume and sperm concentration.A longer time to produce semen samples(Q3 and Q4)was negatively correlated with progressive and total sperm motility.In addition,there was a significant negative linear association between the semen collection time and the sperm morphology.Higher risks of asthenozoospermia(adjusted odds ratio[OR]=2.06,95%confidence interval[CI]:1.31-3.25,P=0.002)and teratozoospermia(adjusted OR=1.98,95%CI:1.10-3.55,P=0.02)were observed in Q3 than those in Q1.Our results indicate that a higher risk of abnormal semen parameter values was associated with an increase in time for semen collection,which may be related to male fertility through its association with semen quality.

关 键 词：ASTHENOZOOSPERMIA semen collection time semen quality TERATOZOOSPERMIA 

分 类 号：R697[医药卫生—泌尿科学]