National Key R&D Program of China:Research on the Functional Characteristics of"Special Effects"and"Common Effects"of Acupoints(No.2019YFC1709001);the National Natural Science Foundation of China:Study on the Immune Mechanisms of Macrophage M1/M2 Polarization in the Treatment of Rheumatoid Arthritis by Moxibustion"Strengthening Body Resistance and Eliminating Evil"(No.81973959);Research on"ImmuneInflammation"Molecular Signal Regulation of NLRP3 Inflammasomes in RA with Moxibustion Treatment(No.81774435);Foundation of Sichuan Provincial Administration of Traditional Chinese Medicine:Research on the Mechanism of MIF-GC Rhythm in the Anti-inflammatory Effect of Moxibustion in Treating Rheumatoid Arthritis(No.2018JC007);Science and Technology Innovation Seedling Project of Sichuan Province,China:based on Macrophage M1 Polarization Signaling Pathway TLR4-MyD88-NF-κB and Its Regulatory Molecule TIM-3 Exploring the Effect Mechanism of Moxibustion on Experimental RA Model(No.2022037);Chengdu University of Traditional Chinese Medicine Foundation:Study on the Mechanism of"MIF-target Protein-GC-inflammation"in the AntiInflammatory Effect of Moxibustion in the Treatment of RA(No.QNXZ2018034)。
OBJECTIVE:To test the hypothesis that moxibustion may inhibit rheumatoid arthritis(RA)synovial inflammation by regulating the expression of macrophage migration inhibitory factor(MIF)/glucocorticoids(GCs).METHODS:Fift...
We thank Yinchao Hao and Wande Li for their assistance with sample collection.This study was funded by the National Natural Science Foundation of China(NSFC,31971413);Natural Science Foundation of Hebei Province(NSFHP,C2020205038)to D.L.;Science and Technology Project of Hebei Education Department(QN2019103)to Y.S.
Human commensal species take advantage of anthropogenic conditions that are less likely to be challenged by the selective pressures of natural environments.Their morphological and physiological phenotypes can therefor...
supported by the Natural Science Foundation of Guangdong (2023B1515040016 and 2021B1515120023);the National Natural Science Foundation of China (Grant numbers 82125038,82274123 and 82174054);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01Y036);the Innovation Team Project of Guangdong Provincial Department of Education (2020KCXTD003)and GDUPS (2019);the National Key Research and Development Program of China (2022YFC0867400).
Psychological stress increases the susceptibility to herpes simplex virus type 1(HSV-1)infection.There is no effective intervention due to the unknown pathogenesis mechanisms.In this study we explored the molecular me...
The authors regret that there was a picture error in the Fig.6D1 owing to the image copy mistake of group-CORT when combining the images of different groups.The revision will cause no change with the data value in Fig...
Supported by the National Key Research and Development Program (No.2017YFC1701701);the Postgraduate Innovation Funding Project of Hebei University of Chinese Medicine (No.XCXZZBS2020005)。
Objective: To investigate the role of hippocampal neurodevelopment in the antidepressant effect of baicalin. Methods: Forty male Institute of Cancer Research mice were divided into control, corticosterone(CORT,40 mg/k...
The authors regret that there was a picture error in Fig.5F owing to the inappropriate data statistics—forgetting gating when data collecting and a picture error in Fig.6F owing to the data copy mistake when drawing ...
We are grateful for the technical support of the Molecular Phenotyping,Histopathology and Histomorphometry,Confocal Microscopy,and Physiology Core facilities at MaineHealth Institute for Research.These core facilities are supported by grants P30GM106391,U54GM115516,and P20GM121301 from the National Institute of General Medical Sciences;This work was supported by grant DK095908(to A.H.)from the National Institute of Diabetes,Digestive and Kidney Diseases,National Institutes of Health,USA.
Thyroid hormone excess secondary to global type 3 deiodinase(DIO3)deficiency leads to increased locomotor activity and reduced adiposity,but also to concurrent alterations in parameters of the leptin-melanocortin syst...
supported by the National Natural Science Foundation of China (31972638);the National Key Research and Development Program of China (2016YFD0500502);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD);the Postgraduate Research&Practice Innovation Program of Jiangsu Province (KYCX18_0716);Jiangsu Collaborative Innovation Center of Meat Production and Processing,Quality,Safety Control
Background:Corticotropin-releasing hormone(CRH),the major secretagogue of the hypothalamic-pituitary-adrenal(HPA)axis,is intricately intertwined with the clock genes to regulate the circadian rhythm of various body fu...
the National Natural Science Foundation of China(Nos.81630104 and 81622050).
Objective:Xiaoyao san(XYS)is a classic traditional Chinese medicinal formula.It has been clinically administered to regulate liver function.However,its mechanisms in glucocorticoid-induced hepatic steatosis are unknow...
When vertebrates face stressful events,the hypothalamic–pituitary–adrenal(HPA)axis is activated,generating a rapid increase in circulating glucocorticoid(GC)stress hormones followed by a return to baseline levels.Ho...