Telomere shortening is associated with corticosterone stress response in adult barn swallows  

作　　者：Alessandra COSTANZO Roberto AMBROSINI Marco PAROLINI Manuela CAPRIOLI Simona SECOMANDI Diego RUBOLINI Leonida FUSANI Virginie CANOINE 

机构地区：[1]Department of Environmental Science and Policy,University of Milan,via Celoria 26,I-20133 Milan,Italy [2]Department of Behavioral and Cognitive Biology,University of Vienna,Althanstr.14,1090 Vienna,Austria [3]Konrad Lorenz Institute of Ethology,University of Veterinary Medicine Vienna,Savoyenstr.1a,1160 Vienna,Austria

出　　处：《Current Zoology》2022年第1期93-101,共9页动物学报（英文版）

摘　　要：When vertebrates face stressful events,the hypothalamic–pituitary–adrenal(HPA)axis is activated,generating a rapid increase in circulating glucocorticoid(GC)stress hormones followed by a return to baseline levels.However,repeated activation of HPA axis may lead to increase in oxidative stress.One target of oxidative stress is telomeres,nucleoprotein complexes at the end of chromosomes that shorten at each cell division.The susceptibility of telomeres to oxidizing molecules has led to the hypothesis that increased GC levels boost telomere shortening,but studies on this link are scanty.We studied if,in barn swallows Hirundo rustica,changes in adult erythrocyte telomere length between 2 consecutive breeding seasons are related to corticosterone(CORT)(the main avian GC)stress response induced by a standard capture-restraint protocol.Within-individual telomere length did not significantly change between consecutive breeding seasons.Second-year individuals showed the highest increase in circulating CORT concentrations following restraint.Moreover,we found a decline in female stress response along the breeding season.In addition,telomere shortening covaried with the stress response:a delayed activation of the negative feedback loop terminating the stress response was associated with greater telomere attrition.Hence,among-individual variation in stress response may affect telomere dynamics.

关 键 词：ALLOSTASIS CORTICOSTERONE Hirundo rustica stress response TELOMERE 

分 类 号：Q95[生物学—动物学]