16层螺旋CT对肝硬化不同肝叶灌注成像的研究  

Study of Perfusion of Different Liver Lobe in Hepatic Cirrhosis by 16-slice Spiral CT

作　　者：于伟利[1] 罗健[2] 张晓娜[1] 白芝兰[1] 

机构地区：[1]西安交通大学医学院第二附属医院影像中心 [2]西安市第四人民医院放射科,710004

出　　处：《现代医用影像学》2008年第6期300-302,共3页Modern Medical Imageology

摘　　要：目的:研究肝硬化不同肝叶血流灌注参数的变化特点。材料与方法:采用GE Lightspeed 16层螺旋CT对30例肝硬化组及54例正常对照组于肝门层面行多层动态CT灌注扫描,通过软件后处理得到不同肝叶的血流动力学参数:肝血容量(BV)、肝血流量(BF)、平均通过时间(MTT)、肝动脉灌注指数(HAF),计算得到肝动脉灌注量(HAP)、门静脉灌注量(PVP)、门脉灌注指数(PPI)。采用SPSS 13.0软件对组间参数进行方差分析和LSD-t检验,检验水准α=0.05。结果:正常对照组肝左内叶HAF大于肝右叶,PPI小于肝右叶,差异均有统计学意义(P=0.015)。BV、BF、MTT、HAP及PVP在各肝叶间无显著性差异(P>0.05)。肝硬化组BV、BF、MTT、HAP、PVP、HAF、PPI在各肝叶间均未表现出统计学差异(P>0.05)。结论:正常人不同肝叶血流动力学状况不尽相同,肝硬化时不同肝叶间血供差异的现象消失。Purpose：To study the blood distribution in different liver lobe in hepatic cirrhosis.Materials and Methods：CT scans were performed in 30 patients with hepatic cirrhosis and 54 control subjects.The dynamic CT scans were obtained at the level of hepatic hilum by 16-slice spiral CT.The liver perfusion parameters,including hepatic blood flow（BF）,blood volume（BV）,mean transit time（MTT）,and hepatic arterial fraction（HAF） were calculated by using the CT Perfusion 3 software in the workstation.Then calculated hepatic artery perfusion（HAP）,portal venous perfusion（PVP） and portal vein perfusion index（PPI）.SPSS 13.0 statistical software was used for statistical analysis of variance（ANOVA） and LSD-t test.size of test α=0.05.Results：There exists significant difference in HAF and PPI between left medial lobe and right lobe（P=0.015）.As for BV,BF,MTT,HAP,PVP,there were no signficant difference among the different liver lobes（P〉0.05）.In the cirrhotic group,there were no signficant difference in the perfusion parameters among the different liver lobes（P〉0.05）.Conclusion：There were difference in the perfusion parameters among the different liver lobes of the control group.The difference in the perfusion parameters were disappeared in the hepatic cirrhosis group.

关 键 词：体层摄影 X线计算机 肝硬化 灌注成像 

分 类 号：R575.2[医药卫生—消化系统] R816.5[医药卫生—内科学]